Inhibitory Activity of Linoleic Acid Isolated from Proso and Japanese Millet toward Histone Deacetylase

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概要

• 論文の詳細を見る

• Linoleic acid was isolated from both the methanol extracts of proso and Japanese millet as a histone deacetylase inhibitor. It showed uncompetitive inhibitory activity toward histone deacetylase (IC50=0.51 mM) and potent cytotoxicity toward human leukemia K562 (IC50=68 μM) and prostate cancer LNCaP cells (IC50=193 μM). Millet containing linoleic acid might have anti-tumor activity.

• 社団法人 日本農芸化学会の論文
• 2007-08-23

著者

• KIMURA Ken-ichi

  Department of Biological Chemistry and Food Science, Iwate University

• NISHIZAWA Naoyuki

  Department of Agro-Bioscience, Faculty of Agriculture, Iwate University

• KOSHINO Hiroyuki

  RIKEN

• ESUMI YASUAKI

  RIKEN (The Institute of Physical and Chemical Research)

• KIMURA Ken-ichi

  Laboratory of Chemical Biology, Faculty of Agriculture, Iwate University

• Nishizawa Naoyuki

  Department Of Agricultural Chemistry Faculty Of Agriculture Iwate University

• ABURAI Nobuhiro

  Department of Agro-Bioscience, Faculty of Agriculture, Iwate University

• Esumi Yasuaki

  Riken(the Institute Of Physical And Chemical Research)

• Koshino Hiroyuki

  Advanced Science Institute Riken

• Nishizawa Naoyuki

  Department Of Agro-bioscience Faculty Of Agriculture Iwate University

• Kimura Ken-ichi

  Laboratory Of Chemical Biology Faculty Of Agriculture Iwate University

• Aburai Nobuhiro

  Lab. Of Chemical Biology The United Graduate School Of Agricultural Sciences Iwate Univ.

• Kimura Ken-ichi

  Faculty Of Agriculture Iwate University

• KIMURA Ken-ichi

  Department of Agro-bioscience, Faculty of Agriculture, Iwate University

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