Inhibitory Activity of Linoleic Acid Isolated from Proso and Japanese Millet toward Histone Deacetylase
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概要
- 論文の詳細を見る
Linoleic acid was isolated from both the methanol extracts of proso and Japanese millet as a histone deacetylase inhibitor. It showed uncompetitive inhibitory activity toward histone deacetylase (IC50=0.51 mM) and potent cytotoxicity toward human leukemia K562 (IC50=68 μM) and prostate cancer LNCaP cells (IC50=193 μM). Millet containing linoleic acid might have anti-tumor activity.
- 社団法人 日本農芸化学会の論文
著者
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KIMURA Ken-ichi
Department of Biological Chemistry and Food Science, Iwate University
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NISHIZAWA Naoyuki
Department of Agro-Bioscience, Faculty of Agriculture, Iwate University
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KOSHINO Hiroyuki
RIKEN
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ESUMI YASUAKI
RIKEN (The Institute of Physical and Chemical Research)
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ABURAI Nobuhiro
Department of Agro-Bioscience, Faculty of Agriculture, Iwate University
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