Biosynthesis of Thiamin under Anaerobic Conditions in Saccharomyces cerevisiae

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概要

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• We studied the biosynthetic route of thiamin in Saccharomyces cerevisiae to see whether the route differed under aerobic and anaerobic conditions.Histidine and pyridoxine are the precursors of the pyrimidine moiety of thiamin under aerobic conditions. Formate is incorporated into the pyrimidine via histidine. The incorporation of [^<13>C]formate and [5'-^2H_2]pyridoxine into the pyrimidine was wxaminied under anaerobic donritions. The labels from [^<13>C]formate and [5'-^2H_2]pyridoxine were not incorporated into the pyrimidine under anaerobic conditions, indicating that the biosynthetic pathway of the pyrimidine differed from that under aerobic conditions.On the other hand, [^<15>N]glycine was incorporated into the thiazole under both anaerobic and aerobic conditions. The biosynthetic pathway of the thiazole was therefore unaltered by the O_2 concentration.

• 公益社団法人日本薬学会の論文
• 2000-01-01

著者

• YAMADA Kazuko

  School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women's University

• Yamada Kazuko

  School Of Pharmaceutical Sciences Mukogawa Women's University

• TANAKA Keiko

  School of Pharmaceutical Sciences, Mukogawa Women's University

• Tanaka K

  Laboratory Of Animal Science Kyoto Prefectural University

• Tanaka K

  Chlorella Industry Co. Ltd.

• Tazuya Keiko

  Faculty Of Pharmaceutical Sciences Mukogawa Women's University

• Yamada K

  Health Sci. Univ. Hokkaido Hokkaido Jpn

• TAZUYA Keiko

  School of Pharmaceutical Sciences, Mukogawa Women's University

• KUMAOKA Hiroshi

  School of Pharmaceutical Sciences, Mukogawa Women's University

• Kumaoka Hiroshi

  School Of Pharmaceutical Sciences Mukogawa Women's University

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