Effect of Nebracetam on the Disruption of Spatial Cognition in Rats.
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概要
- 論文の詳細を見る
Central cholinergic hypofunction causes the disruption of spatial cognition, while cholinomimetics improve this disruption in rats. Scopolamine (0.5 mg/kg, i.p.) has also been reported to disrupt radial maze performance in rats. Nebracetam (WEB 1881 FU), a new nootropic candidate, was able to correct this scopolamine-induced disruption of spatial cognition at the dose of 10 mg/kg, p.o. Furthermore, nebracetam enhanced oxotremorine-induced tremors in mice. These results indicate that nebracetam has a cholinergic enhancing effect. The scopolamine-induced disruption of spatial cognition has been previously reported to improve not only by cholinomimetics but also by brain noradrenergic drugs such as L-<I>threo</I>-DOPS and amantadine. Nebracetam reversed the change of brain noradrenaline contents in the frontal cortex and hippocampus in which the noradrenaline content decreased by treatment with scopola mine. Nebracetam also decreased the Δ<SUP>9</SUP>-tetrahydrocannabinol (6 mg/kg, i.p.)-induced disruption of spatial cognition, which was reported to be related to the lymbic noradrenergic function. These results suggest that the cognitive enhancing effect of nebracetam involves not only cholinergic mechanisms but also involves lymbic and hippocampal noradrenergic mechanisms.
- 公益社団法人 日本薬理学会の論文
著者
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Iwasaki Katsunori
Department Of Mathematical Sciences The University Of Tokyo
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Fujiwara Michihiro
Department Of Neuroparmacology Faculty Of Pharmaceutical Sciences Fukuoka University
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Matsumoto Yoshiaki
Department Of Clinical Pharmacokinetics College Of Pharmacy Nihon University
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Matsumoto Yoshiaki
Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University
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