Pharmacokinetic/Pharmacodynamic Modeling and Simulation of Rosuvastatin Using an Extension of the Indirect Response Model by Incorporating a Circadian Rhythm
スポンサーリンク
概要
- 論文の詳細を見る
Pharmacokinetic/pharmacodynamic (PK/PD) modeling and simulation enable the prediction of the effect of a medication in various situations in clinical practice. The aims of this study were to predict the relationships between the effect of rosuvastatin and various factors such as poor compliance, and morning and evening dosages, as well as the change in the pharmacokinetics of rosuvastatin. We characterized the PK/PD model of plasma mevalonic acid (MVA) profiles after rosuvastatin administration and simulated the plasma MVA concentration in various dosage regimens. The plasma rosuvastatin and MVA concentrations reported by Martin et al. were used as the source of PK/PD modeling data. For each simulation, a summary parameter, the area under the plasma MVA concentration–time curves for 24 h in the steady state (AUEC24), was used to characterize the time course of each endpoint. To estimate the influence of PK parameters on rosuvastatin effects, the AUEC24 reduction ratio of baseline levels was simulated from the 0.33—3.0-fold value of each PK parameter estimate. The AUEC24 reduction ratio was 7.7% lower after morning administration than after evening administration. The changes in the PK parameters more prominently affected the AUEC24 reduction ratio after morning administration than after evening administration. The simulated plasma MVA concentrations almost reached their baseline levels in the case of patients who forgot to take rosuvastatin. These results suggest that the parameters can be used to determine the effective rosuvastatin dosage regimen.
著者
-
Ueno Takahiro
Advanced Res. Inst. For The Sci. And Humanities Nihon Univ.
-
Fukuda Noboru
Advanced Res. Inst. For The Sci. And Humanities Nihon Univ.
-
Aoyama Takahiko
Department Of Cardiac Surgery Aichi Medical University
-
Aoyama Takahiko
Dep. Of Clinical Pharmacokinetics School Of Pharmacy Nihon Univ.
-
Watabe Satoshi
Department of Agricultural Chemistry, The University of Tokyo
-
Matsumoto Yoshiaki
Department Of Clinical Pharmacology And Toxicology Showa Pharmaceutical University
-
Omori Takayuki
Department of Clinical Pharmacokinetics, School of Pharmacy, Nihon University
-
Shioya Akemi
Department of Clinical Pharmacokinetics, School of Pharmacy, Nihon University
-
Matsumoto Yoshiaki
Department Of Clinical Pharmacokinetics College Of Pharmacy Nihon University
-
Watabe Satoshi
Department of Clinical Pharmacokinetics, School of Pharmacy, Nihon University
-
Aoyama Takahiko
Department of Clinical Pharmacokinetics, School of Pharmacy, Nihon University
関連論文
- Association of SLC6A9 Gene Variants with Human Essential Hypertension
- Pharmacokinetic/Pharmacodynamic Modeling and Simulation of Rosuvastatin Using an Extension of the Indirect Response Model by Incorporating a Circadian Rhythm
- OJ-289 CD34 Positive Cells in the Coronary Circulation Increase with Cytokines Induced by Ischemic Condition(Acute coronary syndrome, basic/clinical-3 (IHD) OJ49,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese C
- OE-253 Safety of Catheter-based Autologous Bone Marrow Cells implantation Using a Retrograde Injetion Method through Coronary Vein for Therapeutic Angiogenesis(OE43,Regeneration (M),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Jap
- OE-327 Cardiogenic Potential of Dedifferentiated Fat Cells in Vitro and in Vivo(Regeneration (angionenesis/myocardial regeneration)-2 (M) OE55,Oral Presentation (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- Sulfating-Activity and Stability of cDNA-Expressed Allozymes of Human Phenol Sulfotransferase, ST1A31 (^Arg) and ST1A32 (^His), Both of Which Exist in Japanese as Well as Caucasians^1
- PJ-445 Pathophysiological phenotype and lipid profiles in SHR-SP (fa+/+) as a novel animal model for the metabolic syndrome(Diabetes/Obesity 3 (H) : PJ74)(Poster Session (Japanese))
- Zinc-finger transcriptional factor Sall1 induces angiogenesis by activation of the gene for VEGF-A
- Cardiovascular Remodeling and Metabolic Abnormalities in SHRSP.Z-Lepr^/IzmDmcr Rats as a New Model of Metabolic Syndrome
- PJ-565 Antioxidative beta-blocker celiprolol improves the impaired function of EPC in hypertensive rats(Regeneration (angiogenesis/myocardial regeneration)(05)(M),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Soci
- PJ-333 Effects of losartan on function of endothelial progenitor cells in patients with essential hypertension : Clinical trial(Hypertension, clinical(08)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- Losartan Improves the Impaired Function of Endothelial Progenitor Cells in Hypertension via an Antioxidant Effect
- PE-566 Cardiogenic and Angogenic Potentiality of Dedifferentiated Fat Cells in vitro and in vivo(Regeneration (angiogenesis/myocardial regeneration)-3, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OE-275 ARB Improved the Attenuated Endothelial Progenitor Cells (EPCs) Function in Hypertensive Rats(Hypertension, basic-1 (H) OE46,Oral Presentation (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- Effect of Granulocyte-colony Stimulating Factor on Atherosclerotic Plaque Formation in Cholesterol-fed Rabbits(Atherosclerosis, Basic 6 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Complement 3 Changes Vascular Smooth Muscle Cells to the Synthetic Phenotype by Activation of KLF-5(Vascular Smooth Muscle 1 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-088 Development of synthetic pyrrole-imidazole polyamide targeting TGF-β1 as a novel gene therapy for vascular proliferative diseases and progressive renal diseases(Gene Therapy 1 (IHD) : PJ15)(Poster Session (Japanese))
- Pharmacokinetics/Pharmacodynamics of Acetaminophen Analgesia in Japanese Patients with Chronic Pain(Biopharmacy)
- Differential Effects of Buckwheat and Kudingcha Extract on Neuronal Damage in Cultured Hippocampal Neurons and Spatial Memory Impairment Induced by Scopolamine in an Eight-Arm Radial Maze
- Effects of Atorvastatin on Angiogenesis in Hindlimb Ischemia and Endothelial Progenitor Cell Formation in Rats
- PJ-708 Effects of the Implantation of Cord Blood on Myocardial Infarction in Rats(Regeneration (angionenesis/myocardial regeneration)-7 (M) PJ119,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-280 Development of a Novel Strategy of the High Efficiency Angiogenic Gene and Cell Therapy for Myocardial Infarction(Regeneration (angionenesis/myocardial regeneration)-8 (M) PJ47,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meetin
- PJ-192 Amplification of Angiogenic Effects of Peripheral Blood Mononuclear Cells by siRNA Targeting Apoptosis-inducing Genes(Genetics/Genetically engineered models/Gene therapy-3 (M) PJ32,Poster Session (Japanese),The 70th Anniversary Annual Scientific Me
- PJ-540 Risk of Surgery after Coronary Drug-Eluting Stent Implantation(PJ091,Coronary Revascularization, PCI (DES) 3 (IHD),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PJ-153 Effects of G-CSF on Arterial Hyperplasia and Cardiac Remodeling in Rats Acute Myocadial Infarction Model(Acute myocardial infarction, basic-2, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PE-302 Development of the Endothelium-preserved Drug Eluting Stent with Antisense Oligodeoxynucleotides Targeting PDGF A-chain(Restenosis, basic/clinical-3 (IHD) PE51,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese
- 2 Evaluation of the Prospective Observation of Erythropoietin-Administration for the Treatment of Acute Myocardial Infarction (EPO-AMI)(Late Breaking Clinical Trials II,The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- OJ-365 Comparison of Percutaneous Coronary Intervention (PCI), Medical Therapy (MED) and coronary bypass grafts (CABG) on Small Vessel Disease : A Matched Comparison by Quantitative Coronary Angiography (QCA)(Coronary Revascularization, PTCA/Stent/DCA/Rot
- Pharmacokinetic Modeling and Prediction of Plasma Pyrrole-Imidazole Polyamide Concentration in Rats Using Simultaneous Urinary and Biliary Excretion Data
- Calcium-Channel Antagonists Inhibit Marble-Burying Behavior in Mice
- Cholinergic involvement in the improving effects of Yoku-kan-san-ka-chimpi-hange (Yi-Gan-San-Jia-Chen-Pi-Ban-Xia) on the disruption of spatial cognition and the electroconvulsive shock-induced immobilization
- The Scopolamine-Induced Impairment of Spatial Cognition Parallels the Acetylcholine Release in the Ventral Hippocampus in Rats
- Rolipram and Its Optical Isomers, Phosphodiesterase 4 Inhibitors, Attenuated the Scopolamine-Induced Impairments of Learning and Memory in Rats
- Paroxysmal Atrial Fibrillation due to Bronchogenic Cyst
- PJ-310 Telmisartan Enhances Endothelial Progenitor Cells via PPAR-gamma in Rat Hindlimb Ischemia(PJ052,Hypertension, Basic (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- DPJ-061 Fasudil, Rho-Kinase Inhibitor, Enhances Neovascularization Induced by Endothelial Progenitor Cells in Rat Hindlimb Ischemia(DPJ11,Cardiovascular Pharmacology (Basic) (H),Digital Poster Session (Japanese),The 73rd Annual Scientific Meeting of The J
- PJ-413 Eplerenone Enhances Neovascularization Induced by Endothelial Progenitor Cells in Rat Hindlimb Ischemia(Atherosclerosis, basic(07)(IHD),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- Usefulness of a Method for Changing Tube Current during Helical Scanning in Multislice CT
- Correlation between the Physicochemical Property of Some Nonsteroidal Anti-inflammatory Drugs and Changes in Adenosine Triphosphate, Glutathione and Hemoglobin in Rat Erythrocytes(Biopharmacy)
- Inhibition of MMP-9 transcription and suppression of tumor metastasis by pyrrole-imidazole polyamide
- Evaluation of Pharmacokinetic parameters of Cibenzoline after Administration of a Single Oral Dose in Healthy Volunteers
- Evaluation of Pharmacokinetic Parameters of Cibenzoline after Administration of a Single Oral Dose in Healthy Volunteers
- Determination of concentrations of flecainide in human serum by high-performance liquid chromatography on a fluorocarbon-bonded silica gel column
- Population Pharmacokinetic-Pharmacodynamic Modeling of TF-505 Using Extension of Indirect Response Model by Incorporating a Circadian Rhythm in Healthy Volunteers(Biopharmacy)
- 4'-Hydroxylation of Flurbiprofen by Rat Liver Microsomes in Fasting and Feeding Conditions(Biopharmacy)
- Effects of Aspirin and/or Salicylate on Hydrolysis and Glucuronidation of Indomethacin in Rat Erythrocytes and Hepatocytes
- Glucuronidation of Propofol and Its Analogs by Human and Rat Liver Microsomes
- Testicular Toxicity of Mono-n-Butyl Phthalate and Related Phthalates on Bound Iron in Rat Red Blood Cells
- Possible Origin of Rat Testicular Atrophy Induced by Di-n-Butyl Phthalate : Changes in the Activities of Some Enzymes during Rat Testis Perfusion under a Hypoxic Condition and with Mono-n-Butyl Phthalate
- A Computer Program for Pharmacokinetics Based on Maximum Likelihood Estimation Using the Gamma Distribution with a Probability Density Function : Comparison with the Normal Distribution
- Pharmacokinetics of Fluconazole and Fosfluconazole after Intraperitoneal Administration to Peritoneal Dialysis Rats
- Clinical prevention of gastric cancer by Helicobacter pylori eradication therapy : a systematic review
- Relation between histologic gastritis and gastric motility in Japanese patients with functional dyspepsia : evaluation by transabdominal ultrasonography
- Characteristics of Learning and Memory Impairment Induced by *^9-Tetrahydrocannabinol in Rats
- EVALUATION OF INTRAVASCULAR HEMOLYSIS BY HAPTOGLOBIN ADMINISTRATION AFTER PROSTHETIC VALVE REPLACEMENT
- ASSESSMENT OF DONOR HEART FUNCTION IMMEDIATELY AFTER HETEROTOPIC CARDIAC TRANSPLANTATION : Ventricular Function : 53 Annual Scientific Meeting, Japanese Circulation Society
- Cloning and Sequencing of an Ice Nucleation Active Gene of Erwinia uredovora
- Large-scale Production and Purification of an Erwinia ananas Ice Nucleation Protein and Evaluation of Its Ice Nucleation Activity
- Study on the Discrepancy in Responses Given by Patients to Questions Regarding Subjective Symptoms
- Study on Factors that Contribute to Poor Patient Compliance with Medication in Japan
- LONG-TERM PROGNOSIS OF PATIENTS WITH CONGESTIVE HEART FAILURE : 51st Annual Meeting of the Japanese Circulation Society
- -P38-QUANTITATIVE EVALUATION OF SIMULTANEOUS DUAL SINGLE PHOTON EMISSION COMPUTED TOMOGRAFHY IN THE SITES OF ACUTE MYOCARDIAL INFARCTION : COMPARATIVE STUDY WITH MAGNETIC RESONANCE IMAGES (MRI) : RI : FREE COMMUNICATIONS(III) : PROCEEDINGS OF THE 53th ANN
- -549- CARDIOVASCULAR EFFECTS OF CIGARETTE SMOKING ON EXERCISE IN PATIENTS WITH CORONARY ARTERY DISEASE
- Residual Cardiomyocytes and Scintigraphic Findings in Advanced Coronary Artery Disease : Correlation with Technetium-99m-Tetrofosmin and Thallium-201 Single Photon Emission Computed Tomography
- 0979 QUANTITATIVE RESTING TECHNETIUM-99m-TETROFOSMIN IMAGING IN PREDICTING FUNCTIONAL RECOVERY AFTER REVASCULARIZATION : COMPARISON WITH REST-REDISTRIBUTION THALLIUM-201
- -0386- IMPAIRED MYOCARDIAL FATTY ACID UTILIZATION IN PATIENTS WITH EFFORT ANGINA(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
- -0122- IMAPAIRED FATTY ACID UPTAKE IN RELATION TO WALL MOTION ABNORMALITY IN ISCHEMIC BUT VIABLE MYOCARDIUM IDENTIFIED BY THALLIUM-201 REINJECTION(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
- A High-Performance Liquid Chromatographic Determination of Cibenzoline Using Solid-Phase Extraction
- Primary Liposarcoma of the Mediastinum
- Evaluation of serum fetuin-A relationships with biochemical parameters in patients on hemodialysis
- Ecabet sodium induces neuronal nitric oxide synthase-derived nitric oxide synthesis and gastric adaptive relaxation in the human stomach
- Development of a Computer Program, MDGP, for Population Pharmacokinetic Analysis Written Using ANSI C Language on Wide Platforms
- Acute Drug Poisoning at Critical Care Departments in Japan
- Parameter Estimatability of Robust Estimation in Pharmacokinetic Analysis
- Interaction of an Antinucleating Chemical and an Ice Nucleation Active Bacterium : a Case Study with an n-Octylbenzyldimethylammonium Salt and Erwinia ananas(Pesticide Chemistry)
- Alkylbenzyldimethylammonium Salts as Inhibitors for the Ice Nucleating Activity of Erwinia ananas(Pesticide Chemistry)
- Pharmacokinetics of Midazolam in Critically Ill Patients Receiving Continuous Hemodiafiltration using a Polymethyl Methacrylate and/or Polysulfone Membrane
- Duration of Absorption-Enhancing Effect of Sodium Octanoate, Sodium Hexanoate or Glyceryl-1-monooctanoate on Rectal Absorption of Gentamicin in Rabbits
- Tamponade After Open-Heart Surgery With Percutaneous Cardiopulmonary Support
- Improvement of Hospital Preparation for Patient Oriented Service : Tablet of Bitter Tasting-Stomachic Powder
- Optimization and validation of a high-performance liquid chromatographic method with UV detection for the determination of pyrrole-imidazole polyamides in rat plasma
- PHARMACEUTICAL EVALUATION OF HOLLOW TYPE SUPPOSITORIES. IV. IMPROVEMENT OF BIOAVAILABILITY OF PROPRANOLOL IN RABBITS AFTER RECTAL ADMINISTRATION
- PHARMACEUTICAL EVALUATION OF HOLLOW TYPE SUPPOSITORY
- Successfully Treated Infected Left Ventricular Pseudoaneurysm after the Dor Operation
- Determination of pyrrole-imidazole polyamide in rat plasma by liquid chromatography-tandem mass spectrometry
- Development of a Novel Gene Silencer Pyrrole–Imidazole Polyamide Targeting Human Connective Tissue Growth Factor
- Emergent thoracic aortic angioplasty and stenting for middle aortic syndrome in non-specific aortitis
- Short Note on the Infrared Spectrum of Sbcl^-_6 in the Solids of Cross-Linking Poly-N-Vinylcarbazole
- Short Note On Crystal Boundaries In Evaporated Antimony Films
- Crystallization In Amorphous Antimony Films (I)
- Ionic Structure and Properties of Poly-N-Vinylcarbazole Complexed with Antimony(V) Chloride
- Crystallization In Amorphous Antimony Films (II)
- Development of a molecule-recognized promoter DNA sequence for inhibition of HER2 expression
- Development of Pyrrole–Imidazole Polyamide Targeting Fc Receptor Common Gamma Chain for the Treatment of Immune-Complex Related Renal Disease
- Use of carbon fiber as resistive anode wire for position sensitive proportional counter.
- Effect of Nebracetam on the Disruption of Spatial Cognition in Rats.
- Sulfating-Activity and Stability of cDNA-Expressed Allozymes of Human Phenol Sulfotransferase, ST1A3*1 (213Arg) and ST1A3*2 (213His), Both of Which Exist in Japanese as Well as Caucasians.