Residual Cardiomyocytes and Scintigraphic Findings in Advanced Coronary Artery Disease : Correlation with Technetium-99m-Tetrofosmin and Thallium-201 Single Photon Emission Computed Tomography

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A 68-year-old man suffering from chronic heart failure due to coronary artery disease(CAD) underwent rest technetium-99m(^<99m>Tc)-tetrofosmin and thallium-201(^<201>Tl) with reinjection studies, but died thereafter. The heart was removed and sectioned into short-axis slices and examined by gross and microscopic pathologic methods. A close correlation between the amount of residual cardiomyocytes and the level of regional tracer activity in the left ventricular wall was obtained for redistribution ^<201>Tl, reinjection ^<201>Tl and rest ^<99m>Tc tetrofosmin images. The correlation coefficients were r=0.901 for the ^<201>Tl redistribution images, r=0.913 for the ^<201>Tl reinjection images and r=0.917 for the rest ^<99m>Tc-tetrofosmin images. This case report provides further evidence of the validity of SPECT tetrofosmin imaging for the determination of myocardial viability in CAD.
社団法人日本循環器学会の論文
1998-12-20