Long-Term Effects of Delapril Hydrochloride on Procollagen Type III Amino-Terminal Peptide, Left Ventricular Mass and Left Ventricular Function in Hypertensive Patients

概要

論文の詳細を見る
The long-term effect of delapril hydrochloride, a non-sulfhydryl angiotensin converting enzyme inhibitor, on serum concentrations of procollagen type III amino-terminal peptide(PIIIP)and left ventricular mass(LVM)and function were investigated in 15 hypertensive patients. Patients were treated with delapril hydrochloride 30 mg/day po for 12 months. Blood samples and an echocardiogram were obtained before treatment and after 6 and 12 months of treatment. Blood pressure, PIIIP, and LVM significantly decreased associated with an increase in left ventricular fractional shortening and mean systolic and diastolic posterior wall velocity at 6 and 12 months of treatment. Positive correlations between PIIIP and LVM(r=0.49, p<0.005)and negative correlations between PIIIP and left ventricular fractional shortening(r=-0.31, p<0.05)were found. Delapril hydrochloride reduced PIIIP and LVM and improved cardiac function in hypertensive patients.
社団法人日本循環器学会の論文
1998-11-20