The Hydroxyl Radical Generated by an Iron (II)/EDTA/Ascorbate System Preferentially Attacks Tryptophan Residues of the Protein(Food & Nutrition)

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概要

• 論文の詳細を見る

• Iron (II)/EDTA/ascorbate-mediated oxidative damage to specific amino acid residues (tryptophan) of serum albumin was studied. The active species generated by Fe (II)/EDTA/ascorbate preferred to react with tryptophan residues rather than histidine or other amino acids. The observation of preferential damage to tryptophan residues of the protein was fully suported by a model experiment using a tryptophan analogue. The reaction of Fe (II)/EDTA/ascorbate to the protein was significantly suppressed by mannitol and dimethysulfoxide, suggesting the participation of the hydroxyl radical generated via Fenton's reaction. The result was supported by the hydroxyl radical assay using 2-deoxyribose.

• 社団法人日本農芸化学会の論文
• 1989-12-23

著者

• UCHIDA KOJI

  Department of Respiratory Medicine, Juntendo University School of Medicine

• Uchida K

  Nagoya Univ. Nagoya Jpn

• Uchida Koji

  名古屋大学 生命農学研究科

• KAWAKISHI Shunro

  Department of Food Science and Technology, Nagoya University

• Uchida Kanako

  Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni

• Uchida Koji

  Department Of Food Science & Technology Nagoya University

• Enomoto Naoki

  Department of Physics, Okayama University

• Enomoto Naoki

  Department Of Food Science & Technology Nagoya University

• Itakura Koichi

  Laboratory Of Food And Biodynam Ics Department Of Applied Biological Sciences Nagoya University

• Uchida Koji

  Laboratory Of Food And Biodynamics Nagoya University School Of Agriculture

• ITAKURA Koichi

  Department of Food Science & Technology, Nagoya University

• Kawakishi S

  Nagoya University

• Kawakishi Shunro

  Department Of Food And Nutrition Sugiyama Jogakuen University

• Uchida Koji

  Laboratory of Food and Biodynamics, Nagoya University School of Agricultural Science

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