Inhibitory Effect of Histamine H_3-Receptor Antagonist Cimetidine against Copper(II)/Ascorbate-mediated Protein Damage(Food & Nutrition)

スポンサーリンク

概要

• 論文の詳細を見る

• The inhibition of ascorbate-mediated protein damage by the histamine H_2-receptor antagonist, cimetidine, was chemically studied. In the presence of copper(II) ion, ascorbate gave rise to oxidative modification of both a protein and a histidine derivative under simulated physiological conditions (pH 7.2, 37℃), whereas the reactions were entirely inhibited by the addition of cimetidine. The inhibition of protein damage resulted in almost total disappearance of cimetidine within 24 hr and the appearance of two major products, a species (2) assigned as the 2-imidazolone derivative of cimetidine and cimetidine sulfoxide (3). The mechanism for the protective effect of cimetidine against copper(II)/ascorbate-mediated protein damage is discussed.

• 社団法人日本農芸化学会の論文
• 1990-08-23

著者

• UCHIDA KOJI

  Department of Respiratory Medicine, Juntendo University School of Medicine

• Uchida Koji

  Graduate School Of Bioagricultural Sciences Nagoya University

• KAWAKISHI Shunro

  Department of Food Science and Technology, Nagoya University

• Uchida Koji

  Department Of Food Science & Technology Nagoya University

• MITSUI Mika

  Department of Food Science & Technology, Nagoya University

• Uchida K

  Soy Sauce Research Laboratory Kikkoman Corp.

• Mitsui Mika

  Department Of Food Science & Technology Nagoya University

• Kawakishi S

  Nagoya University

• Kawakishi Shunro

  Department Of Food And Nutrition Sugiyama Jogakuen University

関連論文

• Successful Resection of Dermatomyositis Associated with Thymic Carcinoma : Report of a Case
• Prunusols A and B, Novel Antioxidative Tocopherol Derivatives Isolated from the Leaf Wax of Prunus grayana Maxim.(Organic Chemistry)
• Standards of the In Vitro Mutation Frequency Study and the Antimicrobial Activity Study in Gut
• Inhibitory Effect of Histamine H_3-Receptor Antagonist Cimetidine against Copper(II)/Ascorbate-mediated Protein Damage(Food & Nutrition)
• Stimulation of Iron/Ascorbate-dependent Lipid Peroxidation by Histamine(Food & Nutrition)
• Absorption and Excretion of the 8-Hydroxydaidzein in Rats after Oral Administration and Its Antioxidant Effect
• Partial Purification and Characterization of 4-Hydroxybenzoate-polyprenyltransferase in Ubiquinone Biosynthesis of Pseudomonas putida(Biological Chemistry)
• Solubilization of 4-Hydroxybenzoate-polyprenyltransferase from Cell Membrane of Pseudomonas putida and Its Properties(Biological Chemistry)
• Isolation and Partial Characterization of a Cerulenin-sensitive Mutant of Pseudomonas aeruginosa
• Modulatory effects of black tea polyphenols on oxidant-antioxidant profile and expression of proliferation, apoptosis, and angiogenesis-associated proteins in the rat forestomach carcinogenesis model
• Oxidative Damage of Glycated Protein in the Presence of Transition Metal Ion(Food & Nutrition)
• P-494 Polymer-Assisted Solution-phase Synthesis of 15-Deoxy-Δ^-PGJ_2 Derivatives and their Neurite Outgrowth-Promoting Activity
• Prostaglandins from a Zoanthid : Paclitaxel-Like Neurite-Degenerating and Microtubule-Stabilizating Activities
• 16(I-2) Novel Saponins from the Okinawan Starfish Linckia laevigata : Structure Determination, Neuritogenic Activity, and Mechanism of Action
• Selective Oxidation of Tryptophan and Histidine Residues in Protein through the Copper-catalyzed Autoxidation of _L-Ascorbic Acid(Food & Nutrition)
• 2-[3-(2-Thioxopyrrolidin-3-ylidene)methyl]-tryptophan, a Novel Yellow Pigment in Salted Radish Roots(Food & Nutrition Science)
• Cimetidine Anti-ulcer Drug as a Powerful Hydroxyl Radical Scavenger(Food & Nutrition)
• Interspecific Electrofusion of Protoplasts between Aspergillus oryzae and Aspergillus sojae(Microbiology & Fermentation Industry)
• Further Evidence on the Interspecific Protoplast Fusion between Aspergillus oryzae and Aspergillus sojae and Subsequent Haploidization, with Special Reference to Their Production of Some Hydrolyzing Enzymes(Microbiology & Fermentation Industry)
• Breeding of New Koji-molds through Interspecific Hybridization between Aspergillus oryzae and Aspergillus sojae by Protoplast Fusion(Microbiology & Fermentation Industry)
• Oxidative Depolymerization of Polysaccharides Induced by the Ascorbic Acid-Copper Ion Systems(Food & Nutrition)
• Reactivity of Amylose and Dextran in Metal-Catalyzed Hydroxyl Radical Generating Systems(Food & Nutrition)
• Osteopontin expression in pulmonary tumor thrombotic microangiopathy caused by gastric carcinoma
• New Potent Antioxidative o-Dihydroxyisoflavones in Fermented Japanese Soybean Products
• Formation Mechanism for Potent Antioxidative o-Dihydroxyisoflavones in Soybeans Fermented with Aspergillus saitoi
• Potent Antioxidative Isoflavones Isolated from Soybeans Fermented with Aspergillus saitoi
• Inhibitory Effects of Caffeic Acid Ethyl Ester on H_2O_2-induced Cytotoxicity and DNA Single-strand Breaks in Chinese Hamster V79 Cells
• Suppression of Hydrogen Peroxide-induced Cytotoxicity toward Chinese Hamster Lung Fibroblasts by Decylubiquinone, a Coenzyme Q Homolog
• Antioxidative and Prooxidative Activity of Caffeic Acid toward H_2O_2-induced DNA Strand Breakage Dependent on the State of the Fe Ion in the Medium
• Suppression of Hydrogen Peroxide-induced Mammalian Cytotoxicity by Nordihydroguaiaretic Acid
• Occurrence of Stereoisomers of 1-(2'-Pyrrolidinethione-3'-yl)-1,2,3,4-tetrahydro-β-carboline-3-carboxylic Acid in Fermented Radish Roots and Their Different Mutagenic Properties
• Oxidation Product Derived from a Tetrahyro-β-carboline Derivative, the Yellowish Precursor of Processed Radish Root
• Generation of a β-Carboline Derivative, the Yellowish Precursor of Processed Radish Roots, from 4-Methylthio-3-butenyl Isothiocyanate and L-Tryptophan(Food & Nutrition)
• Isolation and Identification of a Novel β-Carboline Derivative in Salted Radish Roots, Raphanus sativus L.(Food & Nutrition)
• Identification of Enolated 2-Thioxo-3-pyrrolidinecarbaldehyde, a New Degradation Product of 4-Methylthio-3-butenyl Isothiocyanate(Food & Nutrition)
• Superoxide-Mediated Oxygenation of Tryptophan Analogues
• OXIDATION REACTION OF AMINO ACID DERIVATIVES CATALYZED BY COPPER (II) AND IRON (II)-COMPLEX
• The Hydroxyl Radical Generated by an Iron (II)/EDTA/Ascorbate System Preferentially Attacks Tryptophan Residues of the Protein(Food & Nutrition)
• Effects of Polyphenol Oxidase Activity in Wheat Flour on Protein-Bound 5-S-Cysteinyldopa Formation in Gluten
• Stimulation of PGI_2 Production by Uric Acid or Tyramine in Rat Aorta Preparations(Biological Chemistry)
• Potentiating Factors of PGI_2 Production of Rat Aortic Ring Preparations(Biological Chemistry)
• Purification and Identification of a Stimulator of PGI_2 Production from Human Placenta(Biological Chemistry)
• Isolation and Identification of Two Stimulators of PGI_2 Production from Fetal Calf Serum(Biological Chemistry)
• Role of Fermentation Conditions on Flavor Stability of Beer
• Role of Free Radicals in Chemiluminescence Generation during the Beer Oxidation Process(Food & Nutrition)
• A Novel Antioxidative Synergist Isolated from Osbeckia chinensis L.(Organic Chemistry)
• Effects of Ionized Cyclodextrin on Decomposition of Allyl Isothiocyanate in Alkaline Solutions
• Kinetic and Thermodynamic Analyses of the Cyclodextrin-Allyl Isothiocyanate Inclusion Complex in an Aqueous Solution
• Decomposition Rate of Allyl Isothiocyanate in Aqueous Solution
• Homomorphisms of Galois groups of solvably closed Galois extensions
• Screening for Antioxidative Activity of Edible Pulses
• Optical Resolution of 1-(Methyl-sulfinyl)-propyl Alk(en)yl Bisulfides, Inhibitors of Platelet Aggregation Isolated from Onion(Food & Nutrition)
• Formation of 2,3-Dihydro-3,4-dihydroxy-5-acetylfuran in the Reaction between D-Fructose and β-Alanine(Food & Nutrition)
• Formation of 3-{N-(2-Formyl-5-hydromethylpyrrolyl)}-propionic Acid, 3-{N-(2-Methyl-3,6-dihydro-4,5,6-trihydroxyl)}-pyridine, and 3-Deoxyglucosone during the Millard Reaction between D-Fructose and β-Alanine
• On Silverman's estimate of regulators
• Regular Representations of Codes and Duality
• Lipid Peroxidation of Liposome Induced by Glucosone.
• Antioxidative Defense Systems in Rice Hull against Damage Caused by Oxygen Radicals
• Oxidative Degradation of β-Cyclodextrin Induced by an Ascorbic Acid-Copper Ion System
• Antioxidative Flavonoids Isolated from Osbeckia chinensis L.
• Role of Active Oxygen Species in the Toxic Effects of Glucosone on Mammalian Cells.
• Radiolytic Chain Reaction of m-Iodophenyl β-D-glucoside with Radical Anion of Carbon Dioxide Produced from Formate

もっと見る 閉じる

スポンサーリンク