Role of Active Oxygen Species in the Toxic Effects of Glucosone on Mammalian Cells.
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概要
- 論文の詳細を見る
Glucosone (D-arabino-hexos-2-ulose), a typical enediol prod-uct formed both in the Maillard reaction and γ-radiolysis of sugars, decreased survival of Chinese hamster lung V79 cells, which were in-cubated under MEM for 4 h. Inhibition of the decrease in cell servival by catalase and SOD suggests the role of active oxygen species, namely H2O2 and O22+, in the biological effects of glucosone. H2O2 was formed in the medium during oxidative degradation of glucosone. Inhibition of the formation of H2O2 by SOD indicates that the formation of H2O2 and the consequent decrease of the cell survival was enhanced by O2-. These results suggest that the mechanisms of the effects of glucosone on the mammalian cells in the absence of Cu2+ are different from those in the presence of Cu2+.
- 財団法人 学会誌刊行センターの論文
著者
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Kawakishi Shunro
Department Of Food And Nutrition Sugiyama Jogakuen University
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NAKAYAMA Tsutomu
Department of Food Science and Technology, Faculty of Agriculture, Nagoya University
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NAKAYAMA Tsutomu
Department of Agricultural Chemistry, The University of Tokyo
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TERAZAWA Kaoru
Department of Food Science and Technology, Faculty of Agriculture, Nagoya University
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