Partial Spontaneous Regression of Hepatocellular Carcinoma: A Case with High Concentrations of Serum Lens Culinaris Agglutinin-reactive Alpha Fetoprotein
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概要
- 論文の詳細を見る
Spontaneous regression of hepatocellular carcinoma (HCC) is rare. There are few reports discussing spontaneous regression associated with serum lens culinaris agglutinin-reactive alpha fetoprotein (AFP-L3). We describe a case of HCC with a high level of AFP-L3, which showed a rapid increase in alpha fetoprotein (AFP) concentration after partial spontaneous regression, and which was then treated successfully. A 71-year-old woman suffering from chronic hepatitis C underwent surgical resection for HCC. Preoperative concentrations of AFP fluctuated; subsequent to a transient decrease, a rapid increase in AFP was observed. AFP-L3 concentration was extremely high. The resected tissue consisted of encapsulated moderately differentiated HCC, subcapsular coagulation necrosis, and chronic active hepatitis. The postoperative course was uneventful. At present, 24 months after diagnosis, no symptoms or signs of tumor recurrence or metastasis have been observed. Although the precise etiology of the spontaneous regression in this patient is not known, we speculate that spontaneous regression of tumor cells with high malignant potential may be related to arterial involvement and insufficient blood supply.
- 久留米大学医学部の論文
著者
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SATA Michio
Department of Digestive Disease Information & Research
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YAMAMOTO Hiroshi
Department of Macromolecular Science, Graduate School of Science, Osaka University
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Yano Yoichi
佐賀病院(社会保険)
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YANO YOICHI
Department of Medicine, Saga Social Insurance Hospital
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YAMASHITA FUMIHIKO
Department of Medicine, Saga Social Insurance Hospital
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KUWAKI KOTARO
Department of Medicine, Saga Social Insurance Hospital
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FUKUMORI KAZUTA
Department of Medicine, Saga Social Insurance Hospital
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KATO OSAMU
Department of Medicine, Saga Social Insurance Hospital
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KIYOMATSU KAZUMITSU
Department of Surgery, Saga Social Insurance Hospital
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SAKAI TAKENORI
Department of Surgery, Saga Social Insurance Hospital
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YAMASAKI FUMIO
Department of Pathology, Saga University
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ANDO EIJI
Department of Medicine, Kurume University School of Medicine
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Ando Eiji
Department Of Chemistry Faculty Of Science Kyoto University
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Sakai Takenori
Department Of Surgery Kurume University School Of Medicine
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Yamasaki Fumio
Department Of Cardiovascular Surgery Shizuoka City Hospital
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Kiyomatsu Kazumitsu
Department Of Surgery National Kyushu Medical Center Hospital
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Kato Osamu
Department Of Agricultural Chemistry Faculty Of Agriculture Kinki Daigaku University
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Yamamoto Hiroshi
Departmemt Of Chemical Engineering University Of Tokyo
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FUKUMORI Kazuta
Department of Gastroenterology, National Kyushu Medical Center, Fukuoka
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