A Case of Acute Exacerbation of Chronic Hepatitis B Accompanied by Antibody to HBeAg with Remission of Liver Damage after Long-term Treatment with Interferon.
スポンサーリンク
概要
- 論文の詳細を見る
The patient was a 47-year-old female with chronic hepatitis B having antibody to HBe antigen (HBeAg). She was admitted to our hospital in March, 1994, because of acute exacerbation of chronic hepatitis B. Laboratory data revealed the elevated serum transaminase and DNA-polymerase levels, and decreased prothrombin activity. The histological examination of the liver showed chronic active hepatitis with severe hepatic necrosis. Point mutation of the precore region of HBV-DNA (pre-C mutant) was observed in clones from this case by polymerase chain reaction method. The patient was treated with recombinant interferon α-2a 9 MU daily for 2 weeks and thereafter 3 times weekly for 6 months. After interferon therapy, the pre-C mutant disappeared with the improvement of transaminase levels and prothrombin activity. These finidings suggest the possibility that longterm treatment with interferon therapy is effective for the acute exacerbation of chronic hepatitis B accompanied by antibody to HBeAg.
- 久留米大学医学部 The Kurume Medical Journal 編集部の論文
著者
-
Abe Hirohiko
Department Of Respiratory Medicine Hashima City Hospital
-
SATA Michio
Department of Digestive Disease Information & Research
-
Noguchi Seiji
Department Of Hepatology Osaka City University Graduate School Of Medicine
-
Suzuki Hiroshi
Department Of Allergy And Immunology National Research Institute For Child Health & Development
-
Tanikawa Kyuichi
Department Of Digestive Disease Information And Research Kurume University School Of Medicine
-
MURAOKA HARUO
Department of Medicine, Kurume University School of Medicine
-
NOGUCHI SEIJI
Department of Medicine, Kurume University School of Medicine
-
SANEFUJI TOSHIAKI
Department of Internal Medicine, Kumamoto Central Hospital
-
KEIDA RYUJI
Department of Internal Medicine, Kumamoto Central Hospital
-
TSUJI RIKO
Department of Internal Medicine, Kumamoto Central Hospital
-
UCHIMURA YASUYO
Department of Medicine, Kurume University School of Medicine
-
MURAOKA HARUO
Department of Internal Medicine, Kumamoto Central Hospital
-
SATA MICHIO
Department of Medicine, Kurume University School of Medicine
関連論文
- Renoprotective Effect of the Addition of Losartan to Ongoing Treatment with an Angiotensin Converting Enzyme Inhibitor in Type-2 Diabetic Patients with Nephropathy
- Inhibitory Effect of Valsartan Against Progression of Left Ventricular Dysfunction After Myocardial Infarction : T-VENTURE Study
- OE-410 Long-term Effects of Dietary-lifestyle Modification at 6 months after Hospital Discharge in Patients with Acute Myocardial Infarction(OE69,ACS/AMI (Clinical/Treatment) 2 (IHD),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Ja
- OE-260 Impact of Cardiac Rehabilitation on 10-year Mortality in Patients with Acute Myocardial Infarction(OE44,Exercise Test/Cardiac Rehabilitation (H),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- OE-256 Effects of Cardiac Rehabilitation are Pronounced in Elderly Patients with Acute Myocardial Infarction(OE44,Exercise Test/Cardiac Rehabilitation (H),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- Small LDL-Cholesterol is Superior to LDL-Cholesterol for Determining Severe Coronary Atherosclerosis
- Supplement improves nutrition and stresses caused by examination-associated fasting in patients with liver cirrhosis
- Guidelines for the antiviral therapy of hepatitis C virus carriers with normal serum aminotransferase based on platelet counts
- Identification of new immunogenic peptides in conserved regions of hepatitis C virus (HCV) 1b with the potentiality to generate cytotoxic T lymphocytes in HCV1b^+ HLA-A24^+ patients
- Timing of interferon therapy and sources of infection in patients with acute hepatitis C
- OE-410 Long-term Effects of Dietary-lifestyle Modification at 6 months after Hospital Discharge in Patients with Acute Myocardial Infarction(OE69,ACS/AMI (Clinical/Treatment) 2 (IHD),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Ja
- Scleroderma and Repeated Spontaneous Abortions Treated with Vitamin E — A Case Report —
- Incidence and Predictors of Atrial Fibrillation in Subjects without Structural Heart Disease(Preventive Medicine/Epidemiology/Education/Health Policy 1 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Partial Spontaneous Regression of Hepatocellular Carcinoma: A Case with High Concentrations of Serum Lens Culinaris Agglutinin-reactive Alpha Fetoprotein
- EPIDEMIOLOGICAL STUDY OF INFLUENZA VIRUS INFECTIONS IN YANGON, MYANMAR
- Effect of the Composition and Coating Condition on the Structure and Performance of Catalyst Layer of PEFC
- Dispersion Control of Nano-Particles and the Effect of the Coating Condition on the Performance of Proton-Exchange Membrane Fuel Cells (PEMFCs)
- Novel mutations identified in the human multidrug resistance-associated protein 2 (MRP2/ABCC2) gene in a Japanese patient with Dubin-Johnson syndrome
- Identification of New Isotopes ^Pd and ^Pd Produced by In-Flight Fission of 345 MeV/nucleon ^U : First Results from the RIKEN RI Beam Factory(Nuclear physics)
- Gelatinous transformation of bone marrow with pancytopenia in an emaciated patient with systemic lupus erythematosus
- Inflammatory myopathy associated with hepatitis C virus infection: a report of four cases
- Recurrence and Persistence of Fever in Children Who Developed Amantadine-Resistant Influenza Viruses after Treatment
- Effectiveness of Oseltamivir Treatment among Children with Influenza A or B Virus Infections during Four Successive Winters in Niigata City, Japan
- An Off-Seasonal Amantadine-Resistant H3N2 Influenza Outbreak in Japan
- Emergence of amantadine-resistant influenza A viruses : epidemiological study
- THE SIMULIIDAE (DIPTERA) FROM THE SOLOMON ISLANDS, SOUTH PACIFIC
- Event Rates of Acute Myocardial Infarction and Coronary Deaths in Niigata and Nagaoka Cities in Japan
- FIC1-mediated stimulation of FXR activity is decreased with PFIC1 mutations in HepG2 cells
- OE-352 Adiponectin Transgenic Mice Prevents Neointimal Hyperplasia after Vascular Injury(Restenosis basic/clinical-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Contingent negative variation in children with orthostatic dysregulation
- Direct action of an angiotensin II receptor blocker on angiotensin II-induced left atrial conduction delay in spontaneously hypertensive rats
- Validity and Reliability of Single-item Questions about Physical Activity
- Long-Term Survival Following Treatment with Antineoplastons for Colon Cancer with Unresectable Multiple Liver Metastases : Report of a Case
- GB virus C (GBV-C)/hepatitis G virus (HGV) infection in a hepatitis C virus hyper-endemic area in Japan
- Late-onset pneumatosis cystoides intestinalis associated with non-infectious pulmonary complications after allogeneic hematopoietic stem cell transplantation
- Herpes simplex encephalitis and subsequent cytomegalovirus encephalitis after chemoradiotherapy for central nervous system lymphoma : a case report and literature review
- Overweight and obesity increase the risk for liver cancer in patients with liver cirrhosis and long-term oral supplementation with branched-chain amino acid granules inhibits liver carcinogenesis in heavier patients with liver cirrhosis
- OE-167 Eplerenone Suppressed Accumulation of Extra Cellular Matrix in Neointima After Coronary Stent Implantation in Swine(Restenosis after Angioplasty, Basic/Clinical 1 (IHD) : OE20)(Oral Presentation (English))
- PE-530 Cardioprotective Effect of Endogenous Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) on Doxorubicin-Induced Cardiaomyopathy in Mice(PE089,Cardiomyopathy/Hypertrophy (Basic) (M),Poster Session (English),The 73rd Annual Scientific Meeting
- Expression of bone marrow stromal cell specific antigen during murine development : Its expression in embryonic hematopoietic tissues as well as in other developing tissues
- Management of hepatocellular carcinoma : Report of Consensus Meeting in the 45th Annual Meeting of the Japan Society of Hepatology (2009)
- Novel mutations of ATP2A2 gene in Japanese patients of Darier's disease
- PE-052 The Analysis of 2-year Clinical Outcomes due to the Degree of Endothelial-dependent Vasomotion Induced by Acetylcholine after DES Implantation(PE009,Coronary Revascularization, PCI (DES) 2 (IHD),Poster Session (English),The 73rd Annual Scientific M
- DPJ-057 The Effects of Landiolol in Patients with AMI Complicated with Heart Failure(DPJ10,ACS/AMI (Clinical/Treatment) (IHD),Digital Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- OE-072 Increasing Ventricular Pacing Rate Augments Disproportion of Left Ventricular Regional Strain and Perfusion in Patients with Right Ventricular Pacing(OE13,Echo/Doppler (New Technology) (I),Oral Presentation (English),The 73rd Annual Scientific Meet
- FRS-107 Demonstration of Time Sequence of Left Ventricular Mechanical Activation Using Novel Three Dimensional Speckle Tracking Analysis(FRS22,New Echocardiographic Technologies (I),Featured Research Session (English),The 73rd Annual Scientific Meeting of
- QUANTITATIVE RELATIONSHIP BETWEEN IN VIVO BENZODIAZEPINE RECEPTOR OCCUPANCY AND CEREBRAL METABOLIC CHANGE IN THE MOUSE
- BINDING, INTERNALIZATION AND DEGRADATION OF ATRIAL NATRIURETIC PEPTIDE IN ISOLATED CHOROID PLEXUS
- THE TRANSPORT SYSTEM OF BENZYLPENICILLIN IN THE BLOOD-CEREBROSPINAL FLUID BARRIER
- THE TRANSPORT SYSTEM OF CIMETIDINE FROM THE RAT CEREBROSPINAL FLUID : IN VIVO AND IN VITRO STUDIES
- Study on Chlamydia Trachomatis Infection among Students and Pregnant Women in Japan : A Step Toward Developing a Reliable Method for Sexual Behavior Study
- Antibody Reactive to a Hepatitis C Virus (HCV)-Derived Peptide Capable of Inducing HLA-A2 Restricted Cytotoxic T Lymphocytes Is Detectable in a Majority of HCV-Infected Individuals without HLA-A2 Restriction
- Surfactant Drag Reduction Caused by a Cationic Surfactant with Excess Addition of Counter-ions
- Hepatitis B virus genotype G is an extremely rare genotype in Japan
- OE-127 The efficacy and safety of combination use of h-ANP and landiolol (β blocker) with acute coronary syndrome accompanying heart failure.(Heart failure, clinical(02)(M),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circ
- PCR-RFLP Analysis of Cytomegalovirus Infections Associated with Bone Marrow Transplantation in Japanese Children
- Particle Size Characteristics of Ice Slurry Treated with Surfactants and Brines
- Enzyme Histochemical Study of Adrenocortical Adenomas Causing Adrenogental, Cushing's and Conn's Syndromes
- Gauge Invariant Pauli-Villars Regularization of Chiral Fermions : Particles and Fields
- Renormalization Group in 2+ε Dimensions and ε→2 : A Simple Model Analysis
- Electron Impact Ionization of C^+,N^+ and P^+ Ions
- Lack of detection of hepatitis C virus replicative intermediate in abdominal lymph nodes
- Sero-epidemiologic study of hepatitis C virus infection in Fukuoka, Japan
- Sequence Variation of the Hypervariable Region in HCV Carriers with Normal ALT Levels:A Comparison with Symptomatic Carriers
- Benefits of quantitative gated SPECT in evaluation of perioperative cardiac risk in noncardiac surgery
- MANAGEMENT AND PROBLEM OF ENDOSCOPIC BILIARY DRAINAGE
- Phase I clinical study of a peptide vaccination for hepatitis C virus-infected patients with different human leukocyte antigen-class I-A alleles
- Epidemiological Study on Food Intake and Helicobacter pylori Infection
- Hybrid training of voluntary and electrical muscle contractions reduces steatosis, insulin resistance, and IL-6 levels in patients with NAFLD : a pilot study
- Extended Indication Criteria for Endoscopic Mucosal Resection of Early Gastric Cancer with Special Reference to Lymph Node Metastasis : Examination by Multivariate Analysis
- Radiographic Observation of a Case of Gastrointestinal Stromal Tumor in Stomach
- Clinical Evaluation of Intramuscular Administration of Natural Interferon-γ in the Treatment of Chronic Hepatitis B
- Effect of AGEs on Human Disc Herniation: Intervertebral Disc Hernia Is Also Effected by AGEs
- Immunological Study of the Association between Hepatocyte Damage and HBc Antigen.
- Thyroid Dysfunction Induced by Interferon Therapy for the Treatment of Hepatitis Type C. A Report of 4 Cases.:A Report of 4 Cases
- B-Flow Contrast US with Levovist in Hepatic Tumors: Preliminary Results
- The Importance of a Prior Psychiatric Examination in Pegylated Interferon and Ribavirin Combination Treatment for Chronic Hepatitis C
- Evaluation of First- and Second-Generation Assays for Detection of Antibody to Hepatitis C Virus in non-A, non-B Chronic Liver Diseases. Evaluation of 1st and 2nd-Generation Assays in NANBH.:Evaluation of 1st and 2nd-Generation Assays in NANBH
- Appearance-specific Satiety Increases Appetite and Quality of Life in Patients with Metastatic Liver Tumor: A Case Report
- A Case of Acute Exacerbation of Chronic Hepatitis B Accompanied by Antibody to HBeAg with Remission of Liver Damage after Long-term Treatment with Interferon.
- Asialoglycoprotein Receptor Function of Hepatocytes in Patients with Autoimmune Hepatitis.
- An Experimental Animal Model of Primary Biliary Cirrhosis Induced by Lipopolysaccharide and Pyruvate Dehydrogenase.
- Effects of Interferon .ALPHA. 2a on Incidence of Hepatocellular Carcinoma in Chronic Active Hepatitis without Cirrhosis.
- Markedly Prolonged Jaundice from Simultaneous Infection with Hepatitis E Virus and Leptospira
- A Case of Mediastinal Pancreatic Pseudocyst Successfully Treated with Somatostatin Analogue
- A Patient with Chronic Hepatitis C and a History of Abuse of Analeptic Drugs, Who Showed Hallucination and Delusion with Interferon Administration.
- A Case of Malignant Lymphoma with Hemophagocytic Syndrome Presenting as Hepatic Failure.
- Confocal Laser Microscopy of Chondrocytes That Received Gene Transfer Using in vitro Electroporation.
- Incidence of Antibodies to Hepatitis C Virus in Patients Undergoing Chronic Dialysis and CAPD.
- A Case Report of Primary Hepatic Squamous Cell Carcinoma That Remarkably Responded to Low Dose Arterial Injection of Anti-Cancer Drugs
- Function of Asialoglycoprotein Receptor of Hepatocytes in Patients with Wilson's Disease.
- HBV DNA Can Be Detected from Nail Clippings of HBs Ag Positive Patients.
- Vascular Endothelial Growth Factor Is Involved in Angioedema Associated with Eosinophilia
- Endoscopic Ultrasonography-Guided Cystogastrostomy for Large Pancreatic Pseudocyst with Obstructive Jaundice-A Case Report-
- Inhibitory Effect of Antineoplaston A10 and AS2-1 on Human Hepatocellular Carcinoma.
- A Patient with Hyperlipidemia who Had a Gallbladder Stone Caused by Administration of Fenofibrate
- Efficacy and safety of eltrombopag in Japanese patients with chronic liver disease and thrombocytopenia : a randomized, open-label, phase II study
- Data mining reveals complex interactions of risk factors and clinical feature profiling associated with the staging of non-hepatitis B virus/non-hepatitis C virus-related hepatocellular carcinoma
- Development of intrahepatic cholangiocarcinoma after a 14-year follow-up of a patient with primary sclerosing cholangitis and ulcerative colitis
- noninvasive scoring systems in patients with nonalcoholic fatty liver disease with normal alanine aminotransferase levels