Clinical Evaluation of Intramuscular Administration of Natural Interferon-γ in the Treatment of Chronic Hepatitis B
スポンサーリンク
概要
- 論文の詳細を見る
Natural interferon-γ at a dose of 0.5×10<SUP>6</SUP> or 1×10<SUP>6</SUP> IU daily was intramuscularly administered daily for 4 weeks to 15 patients with chronic hepatitis B. The efficacy and safety of the treatment were evaluated for 24 weeks following the completion of the 4-week treatment period. Persistent disappearance of HBeAg was observed in 5 of 15 patients. Serum hepatitis B virus (HBV)-related DNA polymerase disappeared in 5 of 13 patients at the end of interferon therapy. On the other hand, serum ALT and β<SUP>2</SUP>-microglob-ulin levels showed a significant increase during the interferon therapy period. The side effects were completely reversible. These findings suggest that interferon-γ has an antiviral effect in patients with chronic hepatitis B and that the main mechanism of the therapeutic effect may be associated with the elimination of HBV-infected hepatocytes due to the immunopoten-tiating effect of the substance.
著者
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SATA Michio
Department of Digestive Disease Information & Research
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Suzuki Shiro
Department Of Gastroenterology And Hepatology Tokyo Medical University
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Okita Kiwamu
Department Of First Internal Medicine Yamaguchi University School Of Medicine
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Tsuji Takao
Department Of Cardiovascular Medicine Okayama University Graduate School Of Medicine And Dentistry
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Nishioka Mikio
Department Of Gastroenterology And Neurology Kagawa University School Of Medicine
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Kakumu Shinichi
Department Of Gastroenterology Aichi Medical University School Of Medicine
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Mizokami Masashi
Department Of 2nd Internal Medicine Nagoya City University School Of Medicine
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Matsushima Takashi
Department Of Internal Medicine Hakodate Municipal Hospital
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Tanikawa Kyuichi
Department Of Digestive Disease Information And Research Kurume University School Of Medicine
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KUROKI Tetsuo
Department of Rheumatosurgery, Osaka City University Graduate School of Medicine
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KAKUMU SHINICHI
Department of Medicine, Hokkaido University School of Medicine
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MATSUSHIMA TAKASHI
Department of Medicine, Nagoya University School of Medicine
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MIZOKAMI MASASHI
Department of Medicine, Nagoya City University
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OKITA KIWAMU
Department of Medicine, Yamaguchi University School of Medicine
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KUROKI TETSUO
Department of Medicine, Osaka University School of Medicine
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TANIKAWA KYUICHI
Department of Medicine, Kurume University School of Medicine
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