Immunological Study of the Association between Hepatocyte Damage and HBc Antigen.
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概要
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To identify the target antigen during hepatocyte damage in hepatitis type B virus (HBV) infections, the expression of HBc and HBs antigens, and, β<SUB>2</SUB>-microgrobulin (BMG) were studied in liver tissue. Serial changes of serum DNA-polymerase (DNA-P) activity and HBV DNA were also measured. After the onset of acute hepatitis, HBs antigen in liver tissues was observed from many patients; but HBc antigen was rarely detected. In liver tissues of patients with chronic hepatitis, HBs antigen was consistently positive, irrespective of the changes in sGPT. On the other hand, HBc antigen was frequently positive both preceding and during the culmination period for sGPT. The distribution of HBO antigen in the hepatocyte was mostly cytoplasmic. During the same period the serum DNA-P and HBV DNA were frequently positive. Immunoelectron microscopy showed that reaction products with HBc antigen existed in the cytoplasm and the cell membrane. These results indicate that HBc antigens become the target, when HBV infected hepatocytes are eliminated.
- 久留米大学医学部 The Kurume Medical Journal 編集部の論文
著者
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SATA Michio
Department of Digestive Disease Information & Research
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Nakano Hitoshi
Department Of Electrical Engineering School Of Science & Engineering Kinki University
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Suzuki Hiroshi
Department Of Allergy And Immunology National Research Institute For Child Health & Development
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Tanikawa Kyuichi
Department Of Digestive Disease Information And Research Kurume University School Of Medicine
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NAKANO HITOSHI
Department of Internal Medicine, Kurume University School of Medicine
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ONO KATUYUKI
Department of Internal Medicine, Kurume University School of Medicine
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HINO TERUKO
Department of Internal Medicine, Kurume University School of Medicine
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ARITAKA TOMOKI
Department of Internal Medicine, Kurume University School of Medicine
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TANIKAWA KYUICHI
Department of Internal Medicine, Kurume University School of Medicine
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