The Importance of a Prior Psychiatric Examination in Pegylated Interferon and Ribavirin Combination Treatment for Chronic Hepatitis C
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概要
- 論文の詳細を見る
Some patients receiving pegylated interferon and ribavirin treatment for chronic hepatitis C are forced to discontinue the treatment due to psychiatric disorders. We performed a retrospective study to evaluate whether pre-treatment psychiatric examinations could increase successful completion rates for this treatment. Methods: A total of 535 patients who started pegylated interferon-α-2b and ribavirin treatment at 6 hospitals affiliated with our hospital were included in this study. The patients were divided into two groups. Those who had visited a psychiatric clinic before treatment were Group A (N=223), and those who did not visit a psychiatric clinic before treatment were Group B (N=312). We analyzed the rate of discontinuation due to psychiatric disorders in the two groups. Results: The rate of discontinuation due to psychiatric disorders in Group A was found to be significantly lower than that of Group B (1.8% (4⁄223) vs. 6.1% (19⁄312), P=0.035). In Group A, 6.1% (4⁄65) discontinued the treatment due to psychiatric disorders, while the comparable rate in Group B was 27% (19⁄68) (P=0.0004). Among patients who presented with psychiatric symptoms during treatment, the rate of treatment completion was significantly higher in Group A than in Group B (69.2% (18⁄26) vs. 5.0% (1⁄20), P=0.0067). In patients with a history of psychiatric symptoms, no discontinuation due to psychiatric disorder was observed in Group A. Conclusions: A psychiatric examination before pegylated interferon and ribavirin treatment was found to positively contribute to the successful completion of the treatment.
- 久留米大学医学部 The Kurume Medical Journal 編集部の論文
著者
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MORITA Yasuyo
Nagata Hospital
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SATA Michio
Department of Digestive Disease Information & Research
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Kumashiro Ryukichi
Department Of Gastroenterology Kurume University
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Ide Tatsuya
Department Of Internal Medicine Kurume University School Of Medicine
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Ogata Kei
Department Of Gastroenterology And Hepatology Yamaguchi University Graduate School Of Medicine
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Uchimura Naohisa
Department Of Neuropsychiatry Kurume University
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SHIRACHI MIKI
Chikugo City Hospital
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KUHARA KOICHIRO
Department of Medicine, Kurume University School of Medicine
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ARINAGA TERUKO
Department of Medicine, Kurume University School of Medicine
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MIYAJIMA ICHIRO
Department of Medicine, Kurume University School of Medicine
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MURASHIMA SHIRO
Department of Medicine, Kurume University School of Medicine
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KUWAHARA REIICHIRO
Department of Medicine, Kurume University School of Medicine
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AMANO KEISUKE
Yame General Hospital
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FUJIMOTO YUKARI
Yame General Hospital
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SAKAI KENJI
Omuta City Hospital
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ISHII KUNIHIDE
Asakura Medical Association Hospital
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KUMASHIRO RYUKICHI
Department of Medicine, Kurume University School of Medicine
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OGATA KEI
Department of Medicine, Kurume University School of Medicine
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IDE Tatsuya
Department of Aerospace Engineering, Tokyo Metropolitan University
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