Asialoglycoprotein Receptor Function of Hepatocytes in Patients with Autoimmune Hepatitis.
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概要
- 論文の詳細を見る
To assess whether the hepatocyte asialoglycoprotein receptors are affected in patients with autoimmune hepatitis, the function of the hepatocyte asialoglycoprotein receptor was investigated in patients with autoimmune hepatitis or chronic hepatitis C. A new radionuclide liver imaging technique, Technetium-99 m diethylenetriamine-pentaacetic acid-galactosyl human serum albumin, was applied to evaluate the function of the receptor. A Receptor Index (LHL 15) was calculated by dividing the radioactivity of the liver region-of-interest (ROI) by that of the liver plus heart ROI 15 min after radiolabeled ligand injection. Serum albumin, prothrombin time, hepaplastin test and plasma retention rate of indocyanine green at 15 min were not significantly different between patients in the autoimmune hepatitis group and chronic hepatitis C group. In addition, the Receptor Index of patients with autoimmune hepatitis, in whom the asialoglycoprotein receptor is a candidate target antigen for autoimmune response, was similar to that of patients with chronic hepatitis C. These results indicate that the hepatocyte receptor for asialoglycoproteins is not affected in patients with autoimmune hepatitis.
- 久留米大学医学部 The Kurume Medical Journal 編集部の論文
著者
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SATA Michio
Department of Digestive Disease Information & Research
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Harada Masaru
Department Of Community Medicine The Japan Medical Association
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Nakano Hitoshi
Department Of Electrical Engineering School Of Science & Engineering Kinki University
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Sakisaka Shotaro
Department Of Gastroenterology And Hepatology Fukuoka University School Of Medicine
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Itano Satoshi
Department Of Surgery Terada Hospital
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Tanikawa Kyuichi
Department Of Digestive Disease Information And Research Kurume University School Of Medicine
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Yoshida Hiroshi
Departmen Of Radiology School Of Medicine Asahikawa Medical University
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NAKANO HITOSHI
Departments of Medicine Kurume University School of Medicine
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ISHIBASHI MASATOSHI
Radiology Kurume University School of Medicine
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OHISHI MASAHITO
Departments of Medicine Kurume University School of Medicine
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MIYAZIMA ICHIRO
Departments of Medicine Kurume University School of Medicine
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YOSHITAKE MASAO
Departments of Medicine Kurume University School of Medicine
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HARADA MASARU
Departments of Medicine Kurume University School of Medicine
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