Function of Asialoglycoprotein Receptor of Hepatocytes in Patients with Wilson's Disease.
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概要
- 論文の詳細を見る
The function of hepatocyte asialoglycoprotein receptors was analyzed in normal subjects, in patients with Wilson's disease and in patients with chronic hepatitis C. A new radionucide liver imaging, using Technetium-99 m diethylenetriamine-pentaacetic acid-galactosyl human serum albumin, was applied to evaluate the function of the receptor, and a Receptor Index, LHL 15, which was calculated by dividing the radioactivity of the liver region-of-interest (ROT) by that of the liver plus heart ROT at 15 min after the radiolabeled ligand injection, was evaluated. The values were similar between the patients with Wilson's disease and patients with chronic hepatitis C. Hepatocyte receptors for asialoglycoproteins were not affected specifically in patients with Wilson's disease, suggesting that the defect in patients with Wilson's disease involves steps other than receptor-mediated endocytosis of asialoceruloplasmin via asialoglycoprotein receptor.
- 久留米大学医学部 The Kurume Medical Journal 編集部の論文
著者
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SATA Michio
Department of Digestive Disease Information & Research
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Harada Masaru
Department Of Community Medicine The Japan Medical Association
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Sakisaka Shotaro
Department Of Gastroenterology And Hepatology Fukuoka University School Of Medicine
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Itano Satoshi
Department Of Surgery Terada Hospital
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Tanikawa Kyuichi
Department Of Digestive Disease Information And Research Kurume University School Of Medicine
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SAKISAKA SHOTARO
Departments of Medicine Kurume University School of Medicine
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ISHIBASHI MASATOSHI
Radiology Kurume University School of Medicine
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OHISHI MASAHITO
Departments of Medicine Kurume University School of Medicine
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MIYAZIMA ICHIRO
Departments of Medicine Kurume University School of Medicine
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YOSHITAKE MASAO
Departments of Medicine Kurume University School of Medicine
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TANIKAWA KYUICHI
Departments of Medicine Kurume University School of Medicine
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