Effects of Interferon .ALPHA. 2a on Incidence of Hepatocellular Carcinoma in Chronic Active Hepatitis without Cirrhosis.
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概要
- 論文の詳細を見る
To determine the incidence of hepatocellular carcinoma among patients with chronic hepatitis C who received interferon (IFN) therapy, 63 patients with chronic hepatitis C who underwent IFN therapy (IFN α 2a 9 X 10<SUP>6</SUP>IU daily for 2 weeks and followed 9×10<SUP>6</SUP>IU three times weekly for 14 weeks) from January to December 1992, were studied. Selection criteria were as follows: within six months before IFN therapy patients were diagnosed with chronic active hepatitis without cirrhosis by hepatic histological examination, and were hepatitis C virus antibody positive. Furthermore, patients had records of follow-up liver function tests (once a month) for more than six months after IFN therapy completion, and of ultrasound scanning (once in three to four months) before and for at least more than six months after the therapy completion. An average period of observation was 2.7 years (0.6 to 3.8 years). Twenty five of 63 patients (39.7%) returned to normal values of serum ALT, whereas 38 of 63 (60.3%) still showed abnormal values at six months after IFN therapy completion. Nine of 63 (14.2%) and 6/63 (9.5%) developed cirrhosis and hepatocellular carcinoma, respectively. All patients who developed cirrhosis and hepatocellular carcinoma were from those (n=38) that showed abnormal ALT values after therapy completion. The five of six patients that progressed to hepatocellular carcinoma were associated with cirrhosis. No patients who returned to normal ALT values developed hepatocellular carcinoma during the period of observation. These results suggest that IFN therapy is effective to prevent the development of hepatocellular carcinoma.
- 久留米大学医学部 The Kurume Medical Journal 編集部の論文
著者
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SATA Michio
Department of Digestive Disease Information & Research
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Noguchi Seiji
Department Of Hepatology Osaka City University Graduate School Of Medicine
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Fukuizumi Kunitaka
Department Of Gastroenterology Kyushu Medical Center National Hospital Organization
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Suzuki Hiroshi
Department Of Allergy And Immunology National Research Institute For Child Health & Development
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Ide Tatsuya
Department Of Internal Medicine Kurume University School Of Medicine
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Sasaki Masaru
Department Of Electrical Communications Faculty Of Engineering Tohoku University
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Tanikawa Kyuichi
Department Of Digestive Disease Information And Research Kurume University School Of Medicine
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UCHIMURA YASUYO
Department of Medicine, Kurume University School of Medicine
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SHIRACHI MIKI
Department of Medicine, Kurume University School of Medicine
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AKIYOSHI FUYUHIKO
Department of Medicine, Kurume University School of Medicine
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IDE Tatsuya
Department of Aerospace Engineering, Tokyo Metropolitan University
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TANIKAWA KYUICHI
Department of Medicine, Kurume University School of Medicine
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