The Structure of a New Cardenolide Diglycoside and the Biological Activities of Eleven Cardenolide Diglycosides from Nerium oleander

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概要

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• A new cardenolide diglycoside (1) was isolated from Nerium oleander together with ten known cardenolide diglycosides 2—11. The structure of compound 1 was established on the basis of their spectroscopic data. The in vitro anti-inflammatory activity of compounds 1—11 was examined on the basis of inhibitory activity against the induction of the intercellular adhesion molecule-1 (ICAM-1). Compounds 2—5 were active at an IC50 value of less than 0.8 μM. The cytotoxicity of compounds 1—11 was evaluated against three human cell lines normal human fibroblast cells (WI-38), malignant tumor cells induced from WI-38 (VA-13), and human liver tumor cells (HepG2). Compound 3 was active toward VA-13 cells, and compounds 2—5 were active toward HepG2 cells at IC50 values of less than 1.3 μM. The multidrug resistance (MDR)-reversal activity of compounds 1—11 was evaluated on the basis of the amount of calcein in MDR human ovarian cancer 2780AD cells in the presence of each compound. Compounds 1 and 8 showed moderate effects on calcein accumulation.

• 社団法人 日本薬学会の論文

著者

• Kataoka Takao

  Center For Biological Resources And Informatics Tokyo Institute Of Technology

• Hirose Katsutoshi

  KNC Laboratories Co., Ltd.

• Ando Masayoshi

  Department of Applied Chemistry, Niigata University

• SAKAI Jun-ichi

  Department of Chemistry and Chemical Engineering, Niigata University

• Zhao Ming

  College of Chemistry and Chemical Engineering, Qiqihar University

• Bai Liming

  College of Chemistry and Chemical Engineering, Qiqihar University

• Toki Asami

  Graduate School of Science and Technology, Niigata University

• Hasegawa Ryo

  Graduate School of Science and Technology, Niigata University

• Hasegawa Toshiaki

  Mitsubishi Gas Chemical Company, Inc., Niigata Research Laboratory

• Ogura Hirotsugu

  Center for Biological Resources and Informatics, Tokyo Institute of Technology

• Bai Yuhua

  Department of Medicinal Chemistry, Pharmaceutical Department, Daqing Campus of Harbin Medical Univer

• Ando Mariko

  Technical Division, School of Engineering, Tohoku University

• Hirose Katsutoshi

  Knc Lab. Co. Ltd. Hyogo Jpn

• Hasegawa Toshiaki

  Mitsubishi Gas Chemical Company Inc. Niigata Research Laboratory

• Bai Liming

  College Of Chemistry And Chemistry Engineering Qiqihar University

• Zhao Ming

  College Of Chemistry And Chemistry Engineering Qiqihar University

• Hasegawa Ryo

  Graduate School Of Science And Technology Niigata University

• Bai Yuhua

  Department Of Medicinal Chemistry Pharmaceutical Department Daqing Campus Of Harbin Medical Universi

• Toki Asami

  Graduate School Of Science And Technology Niigata University

• Sakai Jun-ichi

  Department Of Applied Mathematics And Physics

• Ogura Hirotsugu

  Center For Biological Resources And Informatics Tokyo Institute Of Technology

• Bai Yuhua

  Department of Medicinal Chemistry, Pharmaceutical Department, Daqing Campus of Harbin Medical University

• Sakai Jun-ichi

  Department of Chemistry and Chemical Engineering, Faculty of Engineering, Niigata University

• ANDO Masayoshi

  Department of Chemistry and Chemical Engineering, Faculty of Engineering, Niigata University

• Sakai Jun-ichi

  Department of Applied Chemistry, Faculty of Engineering, Niigata University

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