Inhibition of Tumor Cell Invasion and Matrix Degradation by Aminopeptidase Inhibitors

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概要

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• We investigated the effects of several types of aminopeptidase inhibitors on tumor cell-associated aminopeptidase activity and invasion. The aminopeptidase expressed by the human metastatic HT1080 fibrosarcoma cells was effectively suppressed by actinonin A, bestatin, leuhistin and matlystatin A, which are capable of inhibiting the purified aminopeptidase N, but not by arphamenine B specific for aminopeptidase B. The aminopeptidase N inhibitors inhibited HT1080 cells from degrading the subendothelial matrix and from invading into Matrigel in parallel with their aminopeptidase inhibitory activities. Matlystatin A, with multiple inhibitory activity against both aminopeptidase N and matrix metalloproteinases (MMP), was the most effective inhibitor of invasion. However, leuhistin and bestatin, without MMP inhibitory activity, also exhibited significant inhibition of invasion. The results suggest that aminopeptidase N plays a crucial role in the degradation and invasion of extracellular matrices by fibrosarcoma cells and that aminopeptidase inhibitors may be useful for preventing the spread of malignant tumors.

• 公益社団法人日本薬学会の論文
• 1996-01-15

著者

• TSURUO TAKASHI

  Institute of Molecular and Cellular Biosciences, University of Tokyo

• Tsuruo Takashi

  Division Of Molecular Oncology Aichi Cancer Center Research Institute

• Tsuruo Takashi

  Institute Of Molecular And Cellular Biosciences The University Of Tokyo

• Tsuruo T

  Division Of Molecular Oncology Aichi Cancer Center Research Institute

• FUJII Hideji

  Institute of Molecular and Cellular Biosciences, The University of Tokyo

• NAKAJIMA Motowo

  Institute of Molecular and Cellular Biosciences, The University of Tokyo

• AOYAGI Takaaki

  Department of Hygenic Chemistry, Showa College of Pharmaceutical Sciences

• Fujii Hideji

  Institute Of Molecular And Cellular Biosciences The University Of Tokyo

• Nakajima Motowo

  Institute Of Molecular And Cellular Biosciences The University Of Tokyo

• Nakajima Motowo

  Institute Of Molecular And Cellular Bioscience The University Of Tokyo

• Aoyagi Takaaki

  Department Of Hygenic Chemistry Showa College Of Pharmaceutical Sciences

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