POTENTIATION OF CHEMOTHERAPEUTIC EFFECT OF VINCRISTINE IN VINCRISTINE RESISTANT TUMOR BEARING MICE BY CALMODULIN INHIBITOR CLOMIPRAMINE
スポンサーリンク
概要
- 論文の詳細を見る
Clomipramine, which is used as antidepressant and possesses calmodulin inhibitory activity, circumvented partly the vincristine resistance in vivo. Although vincristine alone at 30-200μg/kg did not confer a significant therapeutic effect in vincristine resistant P388 leukemia (P388/VCR)-bearing mice, clomipramine at doses of 20 to 50mg/kg administered daily for 10 d with vincristine enhanced the chemotherapeutic effect of vincristine in P388/VCR-bearing mice. Approximately a 30% increase in life span occurred. Although the circumvention of vincristine resistance was not achieved perfectly, it could be speculated that more than 98-99% of vincristine resistant tumor cells which could not be killed by vincristine alone could be killed by this approach.
- 公益社団法人日本薬学会の論文
著者
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TSURUO Takashi
Cancer Chemotherapy Center, Japanese Foundation for Cancer Research
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Sakurai Yoshio
Cancer Chemotherapy Center Japanese Foundation For Cancer Research
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IIDA HARUMI
Cancer Chemotherapy Center, Japanese Foundation for Cancer Research
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NOJIRI MAKIKO
Cancer Chemotherapy Center, Japanese Foundation for Cancer Research
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TSUKAGOSHI SHIGERU
Cancer Chemotherapy Center, Japanese Foundation for Cancer Research
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Tsuruo Takashi
Division Of Molecular Oncology Aichi Cancer Center Research Institute
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Tsuruo Takashi
Cancer Chemotherapy Center Japanese Foundation For Cancer Research
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Tsuruo Takashi
Cancer Chemotherapy Center
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Iida Harumi
Cancer Chemotherapy Center Japanese Foundation For Cancer Research
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Nojiri Makiko
Cancer Chemotherapy Center Japanese Foundation For Cancer Research
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Tsukagoshi S
Japanese Foundation For Cancer Res. Tokyo
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Tsukagoshi Shigeru
Cancer Chemotherapy Center
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Tsukagoshi Shigeru
Cancer Chemotherapy Center Japanese Foundation For Cancer Research
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Taniguchi Tetsuo
The Cancer Chemotherapy Center, Japanese Foundation for Cancer Research (JFCR)
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