Strain Dependent Differences in a Histological Study of CD44 and Collagen Fibers with an Expression Analysis of Inflammatory Response-related Genes in Irradiated Murine Lung

スポンサーリンク

概要

• 論文の詳細を見る

• Using a mouse model, we investigated the mechanisms of heterogeneity in response to ionizing radiation in this research. C57BL/6J and C3H/HeMs mice were irradiated with gamma rays at 10 and 20 Gy. The animals were sacrificed at times corresponding to the latent period, the pneumonic phase, and the start of the fibrotic phase for histological investigation. Small areas of fibrosis initially appeared in C57BL/6J mice at 4 weeks postirradiation with 20 Gy, whereas small inflammatory lesions appeared at 4 and 8 weeks after 20 and 10 Gy, respectively. The alveoli septa were thickened by an infiltration of inflammatory cells, and alveoli were obliterated in lungs from C57BL/6J mice after 20 Gy irradiation. At 24 hours and from 2 to 4 weeks postirradiation, fourfold more CD44 positive cells had accumulated in the lungs of C3H/HeMs than in C57BL/6J mice. Hyaluronan accumulated 12 hours after irradiation, and the rapid resolution was achieved within 2 weeks in the lungs in both strains of mice. C57BL/6J mice lungs accumulated dense collagen at 8 weeks. Quantitative RT-PCR assay was performed for several genes selected by cDNA microarray analysis. The expression of several genes, such as Cap1, Il18, Mmp12, Per3, Ltf, Ifi202a, and Rad51ap1 showed strain-dependent variances. In conclusion, a histological investigation suggested that C3H/HeMs mice were able to induce a more rapid clearance of matrix after irradiation than C57BL/6J mice. The expression analysis showed that the several genes are potentially involved in interstrain differences in inflammatory response causing radiation-induced lung fibrosis.

• 日本放射線影響学会の論文
• 2004-10-10

著者

• Ohno Tatsuya

  放射線医学総合研究所重粒子医科学センター病院

• Imai Takashi

  Radgenomics Research Group National Institute Of Radiological Sciences

• Imai Takashi

  放射線医学総合研究所フロンティア研究センター 放射線感受性遺伝子プロジェクト

• Imai Takashi

  University Of Tokyo

• Imai Takashi

  National Inst. Radiological Sci. Chiba Jpn

• ISHIKAWA Atsuko

  RadGenomics Project, Frontier Research Center, National Institute of Radiological Sciences

• IWAKAWA Mayumi

  RadGenomics Research Group, National Institute of Radiological Sciences

• OHTA Toshie

  RadGenomics Research Group, National Institute of Radiological Sciences

• NODA Shuhei

  RadGenomics Project, Frontier Research Center, National Institute of Radiological Sciences

• IWAKAWA Mayumi

  Frontier Research Center

• NODA Shuhei

  Frontier Research Center

• OOHIRA Chisa

  RadGenomics Project, Frontier Research Center, National Institute of Radiological Sciences

• TANAKA Hiroko

  RadGenomics Project, Frontier Research Center, National Institute of Radiological Sciences

• TSUJI Atsushi

  RadGenomics Project, Frontier Research Center, National Institute of Radiological Sciences

• Izumi Takashi

  Dept. Of Biochem. Gunma Univ. Graduate Sch. Med.

• ISHIKAWA Takahiro

  Natl Inst Radiol Sci

• Oohira Chisa

  放射線医学総合研究所

• Oohira Chisa

  Radgenomics Project National Institute Of Radiological Sciences

• Ohira Chisa

  Radgenomics Project Frontier Research Center National Institute Of Radiological Sciences

• Hirama Toshiyasu

  Research Center For Charged Particle Therapy National Institute Of Radiological Sciences

• Imai Takashi

  Dept. Of Biochem. Gunma Univ. Graduate Sch. Med.

• Imai T

  Rf Heating Laboratory Naka Fusion Research Establishment Japan Atomic Energy Research Institute

• Noda Syuhei

  Radgenomics Project Frontier Research Center National Institute Of Radiological Sciences

• Noda Shuhei

  Radgenomics Project Frontier Research Center National Institute Of Radiological Sciences

• Iwakawa Mayumi

  Radgenomics Research Group National Institute Of Radiological Sciences

• Tanaka Hiroko

  Radgenomics Project Frontier Research Center National Institute Of Radiological Sciences

• Ohta Toshie

  Radgenomics Research Group National Institute Of Radiological Sciences

• Tsuji Atsushi

  Radgenomics Project Frontier Research Center National Institute Of Radiological Sciences

• Ishikawa Atsuko

  National Inst. Radiological Sci. Chiba Jpn

• Ishikawa Atsuko

  Radgenomics Project Frontier Research Center National Institute Of Radiological Sciences

• Ohno Tatsuya

  Department Of Radiation Oncology Graduate School Of Medicine Gunma University

• Iwakawa Mayumi

  Res. Center For Charged Particle Therapy National Inst. Of Radiological Sciences

• Iwakawa Mayumi

  Radgenomics Project Frontier Research Center National Institute Of Radiological Sciences

• Imai Takashi

  Frontier Res. Ctr. Nirs

• Imai Takashi

  Radgenomics Project National Institute Of Radiological Sciences

関連論文

• CT-based 3D Dose-Volume Parameter of the Rectum and Late Rectal Complication in Patients with Cervical Cancer Treated with High-Dose-Rate Intracavitary Brachytherapy
• Current Advancement in Radiation Therapy for Uterine Cervical Cancer
• SF-039-5 FDG-PETを用いた食道癌術前治療の組織学的CR判定 : 重粒子線vs.放射線(食道癌2,サージカルフォーラム,第109回日本外科学会定期学術集会)
• DP-086-7 食道扁平上皮癌に対する重粒子線治療と放射線化学療法施行例におけるFDG-PETによる効果判定(第108回日本外科学会定期学術集会)
• P-272 肺癌炭素線治療後長期生存例の治療前後のCT画像の変化についての検討(放射線療法,第49回日本肺癌学会総会号)
• Current status of microbeam irradiation system for mammalian cells, SPICE at NIRS
• P-10 重粒子線治療を行った非小細胞肺癌症例を対象とした血清プロテオーム解析(一般演題(ポスター) 分子生物学,第48回日本肺癌学会総会)
• Fine adhesion patterning and aligned nuclei orientation of mesenchymal stem cell on narrow line-width of silicone rubber implanted by carbon negative ions (第50回真空に関する連合講演会プロシーディングス)
• Novel function of 9(S)-hydroxyoctadecadienoic acid on proliferation of T cells
• 自己組織化マップを用いた複数MRI画像からの腫瘍診断支援システムの開発
• WS-3-9 直腸癌術後の骨盤内局所再発に対する重粒子線治療(ワークショップ3 再発腫瘍の外科治療法および集学的治療方針-大腸・肛門-,第63回日本消化器外科学会総会)
• DP-158-1 直腸癌術後骨盤内局所再発に対する重粒子線治療の第II相試験(第108回日本外科学会定期学術集会)
• 47 Genes regulated by dominant-negative Ikaros isoform in human T-cell leukemia cell line(Radiation carcinogenesis, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• Carbon Ion Radiotherapy : Clinical Experiences at National Institute of Radiological Science (NIRS)
• Protective Effect of Urinary Trypsin Inhibitor on the Development of Radiation-Induced Lung Fibrosis in Mice
• シリコン電界放出電子源から放出される電子のエネルギー分析
• イオン注入装置の帯電緩和素子への応用を目指したシリコンフィールドエミッタアレイの開発(電子管と真空ナノエレクトロニクス及びその評価技術)
• Potential in a Single Cancer Cell to Produce Heterogeneous Morphology, Radiosensitivity and Gene Expression
• 食道癌に対する粒子線治療
• 重粒子線を用いたがん治療の現状と展望 (特集 がん放射線療法の進歩と展望)
• PD-8-6 切除非適応後腹膜軟部悪性腫瘍に対する炭素イオン線治療の可能性(第108回日本外科学会定期学術集会)
• Dosimetric Factors Used for Thoracic X-Ray Radiotherapy are not Predictive of the Occurrence of Radiation Pneumonitis after Carbon-Ion Radiotherapy
• 窒化ハフニウムフィールドエミッタアレイを用いた真空トランジスタの周波数特性(電子管と真空ナノエレクトロニクス及びその評価技術)
• 三フッ化メタンプラズマ処理したシリコン電界放出電子源の表面状態と電子放出特性(電子管と真空ナノエレクトロニクス及びその評価技術)
• 真空トランジスタのコレクタ形状とコレクタ特性(電子管と真空ナノエレクトロニクス及びその評価技術)
• Irradiation system and physical measurements for heavy-ion radiotherapy.
• CD44 and Bak Expression in IL-6 or TNF-alpha Gene Knockout Mice After Whole Lung Irradiation
• Reliable and Fast Allele-Specific Extension of 3'-LNA Modified Oligonucleotides Covalently Immobilized on a Plastic Base, Combined with Biotin-dUTP Mediated Optical Detection
• Analysis of Non-Genetic Risk Factors for Adverse Skin Reactions to Radiotherapy among 284 Breast Cancer Patients
• Strain-Dependent Differences in Locomotor Activity after Local Brain Irradiation with 30 GyE of Carbon Ions
• Radiosensitivity of Peripheral Blood Lymphocytes Obtained from Patients with Cancers of the Breast, Head and Neck or Cervix as Determined with a Micronucleus Assay
• Fractionated Irradiation Augments Inter-Strain Variation of Skin Reactions among Three Strains of Mice
• Strain Dependent Differences in a Histological Study of CD44 and Collagen Fibers with an Expression Analysis of Inflammatory Response-related Genes in Irradiated Murine Lung
• 259 Radiation sensitivity of 51 human cancer cell lines(Bases of radiotherapy, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• 253 Inter-strain variation of apoptotic index of jejunal crypts between mouse systems after gamma ray whole body irradiation(Apoptosis related, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• 193 Radiosensitivity of the LEC rat(Mutation, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• 100 Correlation with residual γH2AX and radiation susceptibility after irradiation(Repair of radiation damage, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• 69 Inter-strain variation of skin reaction among three strains of mice after fractionated irradiation(Radiation sensitivities in cells & tissues, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• Different Radiation Susceptibility among Five Strains of Mice Detected by a Skin Reaction
• Radiation Sensitive Cells Dedifferentiated from a Cultured Human Esophageal Cancer Cell Line
• Radiation Sensitivity of Breast Cancer Patients as Determined with a Micronucleus Assay.
• Radiosensitivity Analysis of the Mouse Leucocytes by the Use of the Newly Developed Multi- lane Comet Assay
• Mismatch Reair deficiency and Radiosensitivity in Colon Cancer Call Lines
• A Strategy towards Personalized Radiotherapy by Applying Genomic Information
• Measurements of HIMAC Therapy Beam Qualities
• Measurements of Heavy Ion Beam Qualities
• Vascular Homeostasis Regulators, Edn1 and Agpt2, are Upregulated as a Protective Effect of Heat-treated Zinc Yeast in Irradiated Murine Bone Marrow
• ^Cu NMR Study of Spin Dynamics in La_(Sr,Ba)_xCuO_y(0.04≦x≦0.16,3.99≦y≦4.03)
• The Effects of Carbon Ion Irradiation Revealed by Excised Perforated Intestines as a Late Morbidity for Uterine Cancer Treatment
• Phosphorous-31 Magnetic Resonance Spectroscopy of Cervical Cancer Using Transvaginal Surface Coil
• Changes in the Pharmacokinetics of Gd-DTPA in Experimental Tumors after Charged Particle Radiation : Comparison with γ-Ray Radiation
• Comparison of the Radiobiological Effect of Carbon Ion Beam Therapy and Conventional Radiation Therapy on Cervical Cancer
• Relative Biological Effectiveness of 290 MeV/u Carbon Ions for the Growth Delay of a Radioresistant Murine Fibrosarcoma
• RBE of Carbon Ions for Tumor Growth Delay
• Fractionated irradiation with carbon ions induced resistance in mouse gut crypt cells
• Effects of sequentially mixed LET on tumor growth delay
• Fractionated irradiation with carbon ions to gut intestinal crypt cells
• Tumor Induction in Mice Locally Irradiated with Carbon Ions : A Retrospective Analysis
• Nuclear Quadrupole Resonance of Cu in the Paramagnetic State of CuO
• Copper NMR and NQR in La_Sr_xCuO_4-No Evidence for Coexistence of Magnetic Ordering and Superconductivity down to 1.3 K
• 窒化ハフニウムを陰極とした電界放出電子源の作製(電子管と真空ナノエレクトロニクス及びその評価技術)
• Casorati and Discrete Gram Type Determinant Representations of Solutions to the Discrete KP Hierarchy
• Effects of fractionated irradiation with carbon ions on the NFSa fibrosarcoma in mice
• シリコン微小電子源のイオンビーム空間電荷中和への応用(電子管と真空ナノエレクトロニクス及びその評価技術)
• 半球形阻止電界型エネルギー分析器を用いたシリコン電界放出電子源のエネルギー分析
• 水素ガス導入下におけるSi:C電界放出電子源の経時変化の測定
• Observation of Nuclear Resonance of Cu in Pb_2Sr_2Y_Ca_xCu_3O_With x=O and 0.5
• Copper NQR and NMR investingations of Metallic but Nonsuperconducting La_4BaCu_5O_
• Site Assignment for Cu NQR Lines in YBa_2Cu_3O_ Superconductor
• Anomalous Temperature Dependence of Cu Nuclear Spin-Lattice Relaxation in YBa_2Cu_3O_
• Nuclear Spin-Lattice Relaxation of ^Cu at the Cu(2)Sites of the High T_c Superconductor YBa_2Cu_3O_
• NQR and NMR of ^La in Antifrromagnetic La_2CuO_
• Apoptosis Induction in the NFSa tumor after irradiation with carbon ions
• Effects of hypoxic condition on the tumor apoptosis induced by γ irradiation
• Early effects of carbon ion beam on adult mouse brain tissues:damage to the hippocampus
• Biological features of tissue response after fractionated irradiation with carbon ions
• The isoeffect dose of carbon ions depends on LET and fractionation
• Reoxygenation of artificially hypoxic tumors
• Clinical Results of Carbon Ion Radiotherapy at NIRS
• Accelerator Beam Experiments of a Prototype Cosmic Ray Heavy Ion Telescope
• Test of Two-Dimensional Position Sensitive Silicon Detector for Cosmic Ray Telescope by a Light Pulser
• Radiation-Quality Dependent Bystander Effects Induced in Normal Human Fibroblasts by X-ray, Proton and Heavy-Ion Microbeams
• Tumor induction in mouse legs after irradiation with heavy ions
• The Benefit of Small Bowel and Pelvic Bone Sparing in Excluding Common Iliac Lymph Node Region from Conventional Radiation Fields in Patients with Uterine Cervical Cancer : A Dosimetric Study
• Distinct Response of Irradiated Normal Human Fibroblasts and Their Bystander Cells to Heavy-Ion Radiation in Confluent Cultures
• Ceramide Induces Myogenic Differentiation and Apoptosis in Drosophila Schneider Cells
• Biological Effects of Chronically Low-dose Radiation in Heavy-ion Radiation Field.
• Recovery of clonogenic tumor cells after irradiation with carbon ions
• Mouse leg contracture after irradiation with 290 MeV/u C-12 SOBP.
• Mouse Skin Shrinkage after Fractionated Irradiation with Carbon-12 beam
• Intracavitary Combined with CT-guided Interstitial Brachytherapy for Locally Advanced Uterine Cervical Cancer : Introduction of the Technique and a Case Presentation
• Uptake of CDDP-containing Polymeric Micelles by Cells Using Particle Induced X-Ray Emission
• Radiation-induced ICAM-1 Expression via TGF-β1 Pathway on Human Umbilical Vein Endothelial Cells ; Comparison between X-ray and Carbon-ion Beam Irradiation
• Cost-effectiveness of carbon ion radiation therapy for locally recurrent rectal cancer
• High-dose-rate Interstitial Brachytherapy with Computed Tomography-based Treatment Planning for Patients with Locally Advanced Uterine Cervical Carcinoma
• High-dose-rate Interstitial Brachytherapy with Computed Tomography-based Treatment Planning for Patients with Locally Advanced Uterine Cervical Carcinoma
• X-ray irradiation and Rho-kinase inhibitor additively induce invasiveness of the cells of the pancreatic cancer line, MIAPaCa-2, which exhibits mesenchymal and amoeboid motility
• Dose Volume Analysis of Radiotherapy for Inoperable Patients with Stage I-II Endometrial Carcinoma
• Blood Flow Change Quantification in Cervical Cancer before and during Radiation Therapy Using Perfusion CT
• Expression of Hypoxia-inducible Factor 1α Predicts Clinical Outcome after Preoperative Hyperthermo-chemoradiotherapy for Locally Advanced Rectal Cancer

もっと見る 閉じる

スポンサーリンク