Influence of an Adenosine Deaminase Inhibitor, Erythro-9-(2-hydroxy-3-nonyl) Adenine Hydrochloride, on 5-HT2CR mRNA Editing in Primary Cultured Cortical Cells
スポンサーリンク
概要
- 論文の詳細を見る
Treatment of primary cultured cortical cells with erythro-9-(2-hydroxy-3-nonyl) adenine hydrochloride (EHNA), an inhibitor of adenosine deaminase (ADAR), for 6 d significantly and concentration-dependently reduced the editing efficacy at sites C and D but not at site A or B of 5-HT2CR mRNA. The treatment failed to affect the editing of ADAR-2 pre-mRNA and a subunit of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA)-type glutamate receptor (GluR2) mRNA. These findings suggest that EHNA is useful for clarifying the functional roles of 5-HT2CR mRNA editing at sites C and D.
著者
-
Tohda Michihisa
Division Of Medical Pharmacology Institute Of Natural Medicine University Of Toyama
-
Matsumoto Kinzo
Division Of Medicinal Pharmacology Institute Of Natural Medicine Toyama Medical And Pharmaceutical U
-
Tezuka Yasuhiro
Division Of General Thoracic Surgery Department Of Surgery Jichi Medical School
-
Hang Pham
Division Of Medicinal Pharmacology Institute Of Natural Medicine University Of Toyama
関連論文
- Effects of Tokishakuyakusan on the ovary in hypophysectomized rats
- Effects of Tokishakuyakusan on hypothalamic pituitary adenylate cyclase-activating polypeptide (PACAP) and PACAP type I receptor (PAC_1) expression in hypophysectomized and ovariectomized rats
- Effects of Manganese Complexes of Curcumin and Diacetylcurcumin on Kainic Acid-Induced Neurotoxic Responses in the Rat Hippocampus(Pharmacology)
- Hypouricemic Effects of Acacetin and 4,5-O-Dicaffeoylquinic Acid Methyl Ester on Serum Uric Acid Levels in Potassium Oxonate-Pretreated Rats(Pharmacology)
- Constituents of Boesenbergia pandurata and Their cytotoxicity against PANC-1 Cells under Nutrient Deprived Condition(The 24th Annual Meeting of Medical and Pharmaceutical Society for WAKAN-YAKU)
- Antiproliferative Activity of the Netherlands Propolis and Active Constituents
- Corymine Potentiates NMDA-Induced Currents in Xenopus Oocytes Expressing NR1a/NR2B Glutamate Receptors
- Enhanced Expression of BCL2/Adenovirus EIB 19-kDa-Interacting Protein 3 mRNA, a Candidate for Intrinsic Depression-Related Factor, and Effects of Imipramine in the Frontal Cortex of Stressed Mice
- The mRNA Expression Differences of RNA Editing Enzymes in Differentiated and Undifferentiated NG108-15 Cells
- Effects of Choto-san and Its Related Constituents on Endogenous Antioxidant Systems(Pharmacology)
- Antioxidant and Free Radical-Scavenging Activity of Choto-san and Its Related Constituents(Pharmacology)
- Mechanism-Based Inactivation of Human Liver Microsomal CYP3A4 by Rutaecarpine and Limonin from Evodia Fruit Extract
- Buds of Baccharis dracunculifolia : potent source of biologically active caffeoylquinic acids and labdane-type diterpenes of Brazilian propolis
- Effects of Mitragynine on cAMP Formation Mediated by δ-Opiate Receptors in NG108-15 Cells
- Behavioral Studies on Alkaloids Extracted from the Leaves of Hunteria zeylanica
- Permanent Occlusion of Bilateral Internal Carotid Arteries Produces Cognitive Deficits in Two Learning Behavior Tasks
- Tetramethylpyrazine Improves Spatial Cognitive Impairment Induced by Permanent Occlusion of Bilateral Common Carotid Arteries or Scopolamine in Rats
- Anti-hypertensive and anti-stroke effects of Chrysanthemum extracts in stroke-prone spontaneously hypertensive rats
- Imipramine-induced increase in 5-HT2C receptor mRNA level in the rat brain
- Possible Involvement of Signal Transducers and Activators of Transcription 3 System on Depression in the Model Mice Brain
- Chotosan Enhances Macrophage Colony-Stimulating Factor mRNA Expression in the Ischemic Rat Brain and C6Bu-1 Glioma Cells(Biochemistry)
- Chotosan, a Kampo Formula, Ameliorates Chronic Cerebral Hypoperfusion-Induced Deficits in Object Recognition Behaviors and Central Cholinergic Systems in Mice
- Preventive Effect of Chotosan, a Kampo Medicine, on Transient Ischemia-Induced Learning Deficit Is Mediated by Stimulation of Muscarinic M_1 But Not Nicotinic Receptor(Pharmacology)
- Social Isolation Stress-Induced Oxidative Damage in Mouse Brain and Its Modulation by Majonoside-R2, a Vietnamese Ginseng Saponin(Pharmacology)
- The Effects of Choto-san on the mRNA Expression of Alzheimer's Disease Related Factors in the Permanent Ischemic Rat Brain(Pharmacology)
- Expression Changes of the mRNA of Alzheimer's Disease Related Factors in the Permanent Ischemic Rat Brain(Pharmacology)
- Evaluation of the Nitric Oxide Radical Scavenging Activity of Manganese Complexes of Curcumin and Its Derivative(Pharmacology)
- Serotonin 2C Receptor (5-HT2CR) mRNA Editing–Induced Down-Regulation of 5-HT2CR Function in Xenopus Oocytes: the Significance of Site C Editing
- Berberine Exerts Neuroprotective Actions against in Vitro Ischemia-Induced Neuronal Cell Damage in Organotypic Hippocampal Slice Cultures : Involvement of B-Cell Lymphoma 2 Phosphorylation Suppression(Pharmacology)
- Cytoprotective and Cytotoxic Effects of Curcumin : Dual Action on H_2O_2-Induced Oxidative Cell Damage in NG108-15 Cells
- Protective effect of Choto-san and its related constituents on hydrogen peroxide-induced cell damage in NG108-15 cells
- Ameliorative Effects of Paeoniflorin, a Major Constituent of Peony Root, on Adenosine A_1 Receptor-Mediated Impairment of Passive Avoidance Performance and Long-Term Potentiation in the Hippocampus
- Paeoniflorin, a Major Constituent of Peony Root, Reverses Muscarinic M_1-Receptor Antagonist-Induced Suppression of Long-Term Potentiation in the Rat Hippocampal Slice
- Antihypertensive Potential and Mechanism of Action of Astaxanthin : III. Antioxidant and Histopathological Effects in Spontaneously Hypertensive Rats(Pharmacology)
- Antihypertensive Potential and Mechanism of Action of Astaxanthin : II. Vascular Reactivity and Hemorheology in Spontaneously Hypertensive Rats(Pharmacology)
- Developmental Changes in Serotonin 2C Receptor mRNA Editing in the Rat Cerebral Cortex and Primary Cultured Cortical Neurons(Pharmacology)
- Effect of Japanese Angelica Root Extract on Pentobarbital-Induced Sleep in Group-Housed and Socially Isolated Mice:Evidence for the Central Action
- The Possible Involvement of GABA_A Systems in the Antinarcotic Effect of Majonoside-R2, a Major Constituent of Vietnamese Ginseng, in Mice
- A Combination of Soft-Shell Turtle Powder and Essential Oil of a Unicellular Chorophyte Prevents Bone Loss and Decreased Bone Strength in Ovariectomized Rats(Pharmacognosy)
- Four Di-O-caffeoyl Quinic Acid Derivatives from Propolis. Potent Hepatoprotective Activity in Experimental Liver Injury Models
- POTENT ANTIHEPATOTOXIC ACTIVITY OF DICAFFEOYL QUINIC ACIDS FROM PROPOLIS
- Caffeic Acid Phenethyl Ester (CAPE) Analogues: Potent Nitric Oxide Inhibitors from the Netherlands Propolis
- Biological Evaluation and LC-MS Analysis of Propolis from Brazil, Peru, China and the Netherlands : 天然物化学
- Predictors of Postoperative Complications After Radical Resection for Pulmonary Aspergillosis
- Constituents of Water Extract of Brazilian Propolis, Their Biological Properties and Botanical Origin
- Isolation of Two New Flavonoids and Antiproliferative Activity of Chinese Propolis
- Facilitatory and Inhibitory Effects of Harmaline on the Tryptophan- Induced 5-Hydroxytryptamine Syndrome and Body Temperature Changes in Pargyline-Pretreated Rats
- Influence of an Adenosine Deaminase Inhibitor, Erythro-9-(2-hydroxy-3-nonyl) Adenine Hydrochloride, on 5-HT2CR mRNA Editing in Primary Cultured Cortical Cells
- Neuropharmacological Actions of Pluchea indica LESS Root Extract in Socially Isolated Mice
- Serotonin 2C Receptor (5-HT2CR) mRNA Editing-Induced Down-Regulation of 5-HT2CR Function in Xenopus Oocytes : the Significance of Site C Editing
- Extrapulmonary hamartoma
- Berberine Exerts Neuroprotective Actions against in Vitro Ischemia-Induced Neuronal Cell Damage in Organotypic Hippocampal Slice Cultures : Involvement of B-Cell Lymphoma 2 Phosphorylation Suppression
- Kampo Formulations, Chotosan, and Yokukansan, for Dementia Therapy: Existing Clinical and Preclinical Evidence