Pharmacokinetic Study on the Multi-constituents of Huangqin-Tang Decoction in Rats

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概要

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• Using a validated high-performance liquid chromatographic (HPLC) method, the pharmacokinetics of multi-constituents in Huangqin-Tang decoction were simultaneously studied both in the compound prescription and in each single herb decoction. At different intervals (0, 1, 2, 4, 8, 12, 24, 36, 48 h) after oral administration of the Huangqin-Tang decoction or a single herb decoction at a dose of lOg・kg^-1, the concentrations of the constituents and their metabolites: baicalin (BG), wogonoside (WG), oroxylin-A-glucuronide (OG), baicalein (B), wogonin (W), oroxylin-A (O), paeoniflorin (PF), paeonimetabolin-I (PM-I), liquiritin (LG), liquiritigenin (L), glycyrrhizic acid (GL) and glycyrrhetinic acid (GA), were detected in the rat plasma. A new metabolite-3,5,7,2',6'- penta hydroxy flavone (visidulin I, VD-I) was found in rat plasma after oral administration of Huangqin-Tang or a single herb Huangqin decoction, and the quality was identified by HPLC and LC/MS. The pharmacokinetic parameters of the constituents and metabolites in the compound prescription and single herb decoctions were compared. All concentration-time curves corresponded to the one-compartment model. The constituents of BG, WG, OG, VD-I and LG had higher C_<max> and AUC_<0-lim> in the compound prescription than in the single herb decoction, and WG had significant difference. The constituents of PF, W and O only had a higher AUC_<0-lim> in the compound prescription, and O had a significant difference. It was concluded, in brief, that there were obvious differences in the pharmacokinetic parameters of most constituents (especially constituent WG) between the compound prescription and single herb decoction. The constituents in the compound prescription had delayed absorption and elimination, a longer residence time in the body, and higher C_<max> and AUC_<0-lim>, than those in the single herb decoction. Therefore, they were more efficient and durable, making them promising to exerting pharmacological effects in vivo.

• 公益社団法人日本薬学会の論文
• 2003-07-01

著者

• Zuo Feng

  Institute Of Natural Medicine University Of Toyama

• Zhou Zhong-ming

  Institute Of Chinese Materia Medica China Academy Of Traditional Chinese Medicine

• Zuo F

  Toyama Medical And Pharmaceutical Univ. Toyama Jpn

• ZHANG Qing

  Institute of Chinese Materia Medica, China Academy of Traditional Chinese Medicine

• MAO Dan

  Clinical Pharmacology Research Center, Peking Union Medical College Hospital

• XIONG Yu-Lan

  Institute of Chinese Materia Medica, China Academy of Traditional Chinese Medicine

• WANG Yan-Li

  Institute of Chinese Materia Medica, China Academy of Traditional Chinese Medicine

• YAN Mei-Zhen

  Institute of Chinese Materia Medica, China Academy of Traditional Chinese Medicine

• LIU Mei-Lan

  Institute of Chinese Materia Medica, China Academy of Traditional Chinese Medicine

• Wang Y‐l

  Institute Of Chinese Materia Medica China Academy Of Traditional Chinese Medicine

• Wang Yan-li

  Institute Of Chinese Materia Medica China Academy Of Traditional Chinese Medicine

• Zuo Feng

  Institute Of Chinese Materia Medica China Academy Of Traditional Chinese Medicine

• Liu M‐l

  Institute Of Chinese Materia Medica China Academy Of Traditional Chinese Medicine

• Mao Dan

  Clinical Pharmacology Research Center Peking Union Medical College Hospital

• Yan Mei-zhen

  Institute Of Chinese Materia Medica China Academy Of Traditional Chinese Medicine

• Xiong Yu-lan

  Institute Of Chinese Materia Medica China Academy Of Traditional Chinese Medicine

• Zhang Q

  Zhongshan Univ. Guangzhou Chn

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