Equality-evaluation of Wakan-yaku (Japanese-Chinese traditional medicines) with liquid chromatography-mass spectrometry (LC-MS) : comparison of constituents of original plants for Chinese traditional medicine "Dan-shen (Tan-j in)"
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概要
- 論文の詳細を見る
和漢薬は天然物であり,その成分や活性は種,採集時期,産地,個体等,種々の要因に依存する。そのため,均質な和漢薬を用いるには,その成分や活性の同等性を評価した上で用いる必要があり,成分含量や活性の変化を検出する有効な方法が必要とされている。しかし従来法の多くは,少数の代表的成分や活性の比較であり,多成分,多活性を有する和漢薬に適した方法ではなかった。一方,多成分の同時測定が可能なことから,ガスクロマトグラフィ連結質量分析計(GC-MS)や液体クロマトグラフィ連結質量分析計(LC-MS)の応用が近年試みられている。本稿では,種々のタイプの化合物に適応容易なLC-MS法について,我々が行なった漢薬"丹参"の基源植物間の比較を例として述べた。
- 和漢医薬学会の論文
- 2001-04-25
著者
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手塚 康弘
富山大学和漢医薬学総合研究所化学応用分野
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TEZUKA Yasuhiro
Department of Natural Products Chemistry, Institute of Natural Medicine,Toyama Medical and Pharmaceu
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Tezuka Yasuhiro
Department Of Natural Products Chemistry Institute Of Natural Medicine Toyama Medical And Pharmaceut
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Tezuka Yasuhiro
Department Of General Thoracic Surgery Jichi Medical University And Saitama Medical Center
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