A CALCIUM CHANNEL BLOCKER VERAPAMIL INHIBITS THE SPONTANEOUS CLOSURE OF THE DUCTUS ARTERIOSUS IN NEWBORN RATS

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概要

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• Newborn rats delivered by caesarean section were given subcutaneously verapamil hydrochloride (VER), a Ca-channel blocker, (1) immediately or (2) 180 min after delivery. The diameter of the ductus arteriosus (DA) of the newborn pups was calibrated at 30, 60 and 90 min after the VER-administration. (1) The DA calibers of the pups given 0.1, 1.0 mg/kg VER immediately after delivery remained significantly larger than those of control pups in a dose-dependent manner for 30 min after treatment. In the 1 mg/kg group, the enlargement of the DA was prolonged unti1 90 min after treatment. (2) In untreated pups, the DA completely closed by 180 min after caesarean delivery. The closed DA was not affected after 1 mg/kg VER was given at 3 hours after delivery. It was concluded that, VER inhibits the spontaneous constriction of the DA, suggesting that the increase of intracellular Ca^<2+> concentration may play an important role on the spontaneous closure of the DA in newborn rats.

• 日本トキシコロジー学会の論文
• 1994-08-25

著者

• AKAHORI Fumiaki

  Department of Veterinary Pharmacology, School of Veterinary Medicine, Azabu University

• ARISHIMA Kazuyoshi

  Department of Anatomy II School of Veterinary Medicine, Azabu University

• YAMAMOTO Masako

  Department of Anatomy II School of Veterinary Medicine, Azabu University

• ODA Takashi

  Department of Internal Medicine, National Defense Medical College

• SHIOTA Kohei

  Department of Anatomy, Faculty of Medicine, Kyoto University

• Somiya Hiroaki

  Department of LifeSciences, Faculty of Bioresources, Mie University

• Somiya H

  Departments Of Developmental Biotechnology Azabu University School Of Veterinary Medicine

• TAKIZAWA Tatsuya

  Departments of Developmental Biotechnology, Azabu University, School of Veterinary Medicine

• MASAOKA Toshio

  Departments of Pharmacology, Azabu University, School of Veterinary Medicine

• Masaoka T

  School Of Veterinary Medicine Azabu University

• Masaoka Toshio

  Department Of Comparative Toxicology School Of Veterinary Medicine Azabu University

• Akahori F

  School Of Veterinary Medicine Azabu University

• Akahori Fumiaki

  麻布大学 獣医学部実験動物学

• Akahori Fumiaki

  Department Of Veterinary Pharmacology School Of Veterinary Medicine Azabu University Sagamihara

• Akahori Fumiaki

  School Of Veterinary Medicine Azabu University

• Akahori Fumiaki

  Department Of Environmental Health Jichi Medical School : National Institute Of Industrial Health :

• Yamamoto Masako

  Department Of Anatomy Ii School Of Veterinary Medicine Azabu University

• Arishima Kazuyoshi

  Department Of Anatomy Ii School Of Veterinary Medicine Azabu University

• Arishima Kazuyoshi

  Department Of Veterinary Anatomy Ii Azabu University School Of Veterinary Medicine

• Arishima Kazuyoshi

  Anatomy Ii School Of Veterinary Medicine Azabu University

• Arishima Kazuyoshi

  Department Of Anatomy Ii Azabu University School Of Veterinary Medicine

• Yamamoto Masaru

  Laboratories Of Natural Information Science Graduate School Of Integrated Science Yokohama City Univ

• Oda Takashi

  Department Of Chemistry Faculty Of Science Gakushuin University

• Shiota K

  Kyoto Univ. Graduate School Of Medicine Kyoto Jpn

• Sugita Kana

  Department Of Anatomy Ii Azabu University School Of Veterinary Medicine

• Shiota Kohei

  Department Of Anatomy & Developmental Biology And Congenital Anomaly Research Center Graduate Sc

• Shiota Kohei

  Department Of Anatomy And Congenital Anomaly Research Center Faculty Of Medicine Kyoto University

• Somiya Hiroaki

  Department Of Lifesciences Faculty Of Bioresources Mie University

• Yamamoto Masaru

  Laboratories Of Natural Information Science Graduate School Of Integrated Science Yokohama City Univ

• Oda Takashi

  Departments Of Developmental Biotechnology Azabu University School Of Veterinary Medicine

• Yamamoto Masako

  Department Of Anatomy Ii Azabu University School Of Veterinary Medicine

• Kohara Shinya

  Department Of Anatomy Ii Azabu University School Of Veterinary Medicine

• Yamamoto Masahiro

  Center For Kampo Medicine Keio University School Of Medicine

• ARISHIMA Kazuyoshi

  Department of Anatomy II

• TAKIZAWA Tatsuya

  Departments of Developmental and Reproductive Biotechnology, Azabu University School of Veterinary Medicine, Fuchinobe, Sagamihara-shi, Kanagawa 229-8501, Japan

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