Immune Responses in Resistant and Susceptible Strains of CD4-Mutant Mice Infected with Leishmania major
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概要
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We examined the immune response of CD4-mutant mice that have soluble form of CD4 in the circulation without expression of CD4 on T cell surface. We infected the CD4-mutant mice of BALB/c and C57BL/6 backgrounds with Leishmania major and subsequently examined parameters of disease and immune response. In contrast to wild-type (wt) BALB/c mice, mutant mice of both strains showed decreased parasite replication and an intense leishmanial antigen-specific delayed-type hypersensitivity (DTH) response. In vitro cytokine analysis revealed that popliteal lymph node cells (LNC) from mutant mice of both strains secreted little or no detectable interleukin-4 (IL-4) and they secreted interferon-γ (IFN-γ) at levels similar to those of wt mice. The cytokine profile shows that a lack of IL-4 production underlies the lack of T helper type 2 (Th2) response. As validation of the impaired Th2 response, infection of the mice with Nippostrongylus brasiliensis, a typical Th2 inducer, showed a lack of Th2 response. Furthermore, in contrast to LNC from wt mice, Th2 cells were not induced from naive LNC of mutant mice when the cells were cultured in the presence of IL-4 and anti-IL-12 antibody. These findings indicate that the lack of IL-4 production is due to a lack of CD4 on T cells and that IFN-γproduction is independent of CD4 on T cells. Thus, Th1 and Th2 responses to leishmanial infection are not due to the balance of IL-4/IFN-γ that are produced, but the production of IL-4 determines whether a Th1 or Th2 response will develop.
- 2005-02-01
著者
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WATANABE Naoki
Department of Clinical Laboratory, Sapporo Medical University, School of Medicine
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MATSUZAWA Akio
Laboratory Animal Research Center, Institute of Medical Science, University of Tokyo, Tokyo
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Yamakami Kazuo
Department of Preventive Medicine and Public Health, National Defense Medical College
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Yamakami Kazuo
Department Of Public Health National Defense Medical College
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Watanabe N
Department Of Clinical Laboratory Medicine Sapporo Medical University School Of Medicine
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ODA Takashi
Department of Internal Medicine, National Defense Medical College
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TADAKUMA TAKUSHI
Department of Parasitology and Immunology, National Defense Medical College
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Watanabe N
札幌医科大学 医学部臨床研査医学
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Watanabe Naoki
Department Of Clinical Laboratory Medicine Sapporo Medical University School Of Medicine
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Yoshizawa Nobuyuki
Department Of Public Health National Defense Medical College
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NARIUCHI Hideo
Department of Allergology, Institute of Medical Science, The University of Tokyo
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Oda Takashi
Department Of Orthopaedic Surgery Sapporo Medical University School Of Medicine
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Oda Takashi
Department Of Chemistry Faculty Of Science Gakushuin University
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Yoshizawa N
Department Of Public Health National Defense Medical College
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Nariuchi H
Univ. Tokyo Tokyo Jpn
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Nariuchi Hideo
Department Of Allergology Institute Of Medical Science The University Of Tokyo
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Matsuzawa A
Laboratory Animal Research Center Institute Of Medical Science University Of Tokyo Tokyo
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Matsuzawa Akio
Laboratory Animal Research Center Institute Of Medical Science The University Of Tokyo
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Tadakuma T
National Defense Medical Coll. Tokorozawa Jpn
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Tadakuma Takushi
Department Of Microbiology Keio University School Of Medicine
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Watanabe Naoki
Department Of Applied Physics Faculty Of Engineering Tohoku University
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Yamakami Kazuo
Department Of Parasitology And Immunology National Defense Medical College
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Yoshizawa Nobuyuki
Department Of Electrical And Electronic Engineering Nippon Institute Of Technology
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Matsuzawa Akio
Laboratory Animal Research Center
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Yoshizawa Nobuyuki
Department of Chemistry, Faculty of Engineering Science, Osaka University
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