Pure Red Cell Aplasia Associated with Goods Syndrome Accompanied by Decreased Stem Cell Factor Production in the Bone Marrow
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概要
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A 79-year-old Japanese woman diagnosed with pure red cell aplasia (PRCA) associated with thymoma and hypogammaglobulinemia (Goods syndrome) was successfully treated with cyclosporine-A after a thymectomy. We further studied the etiology of this case. A burst-forming unit erythroid (BFU-E) assay with SCF restored erythropoiesis in vitro. SCF production was reduced in bone marrow stromal cells; however, it was restored in vitro and in vivo after cyclosporine-A treatment.
著者
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Takimoto Rishu
The Fourth Department of Internal Medicine Sapporo Medical University
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Kato Junji
The Fourth Department of Internal Medicine Sapporo Medical University
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NIITSU Yoshiro
The Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine
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Watanabe Naoki
Department Of Applied Physics Faculty Of Engineering Tohoku University
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NIITSU Yoshiro
the Fourth Department of Internal Medicine Sapporo Medical College
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Iyama Satoshi
The Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine
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Kikuchi Shohei
The Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine
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KOBUNE Masayoshi
the Fourth Department of Internal Medicine Sapporo Medical College
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Kobune Masayoshi
The Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine
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Kuribayashi Kageaki
Department of Clinical Laboratory Medicine, Sapporo Medical University School of Medicine
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Fujimi Akihito
The Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine
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Takimoto Rishu
The Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine
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