Mice Lacking Protein Tyrosine Kinase Fyn Develop a T Helper-Type 1 Response and Resist Leishmania major Infection
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概要
- 論文の詳細を見る
Fyn is a Src family protein tyrosine kinase associated with TCR/CD3 complex. Fyn appears to play a role in the activation of T cells based on its enzymatic activation and tyrosine phosphorylation following the ligation of TCR/CD3, and it also plays a critical role in the calcium flux and interleukin-2 (IL-2) production. The protective response against murine Leishmania major infection is associated with the T helper-type 1 (Th1) responses and the ability to modulate Th1 cytokines such as IL-2 and interferon-γ, respectively. The role of Fyn tyrosine kinase in vivo was directly examined by the response to infection with L. major in C57BL/6 fyn-deficient mice. Despite the absence of Fyn, the mice remained resistant to this infection with only mild lesion development, and, they demonstrated Th1 responses as assessed by the delayed-type hypersensitivity response and cytokine milieu. The findings in the fyn-deficient mice failed to support a relationship between the anticipated functions of Fyn in vitro and the immune response to L. major infection in vivo. As a result, in leishmanial disease, Fyn probably plays a minor role in the protective immune response and is, therefore, not a key factor in such a response.
- 日本衛生学会の論文
著者
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Yamakami Kazuo
Department of Preventive Medicine and Public Health, National Defense Medical College
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Yamakami Kazuo
Department Of Public Health National Defense Medical College
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TADAKUMA TAKUSHI
Department of Parasitology and Immunology, National Defense Medical College
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Yoshizawa Nobuyuki
Department Of Public Health National Defense Medical College
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Yoshizawa N
Department Of Public Health National Defense Medical College
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Wakabayashi Kazuo
Department Of Public Health National Defense Medical College
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Wakabayashi Kazuo
Department Of Public Health National Defense Medical College:(present Address)department Of Communit
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Akao Shinkichi
Department Of Parasitology And Immunology National Defense Medical College
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Tadakuma T
National Defense Medical Coll. Tokorozawa Jpn
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Tadakuma Takushi
Department Of Microbiology Keio University School Of Medicine
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Yamakami Kazuo
Department Of Parasitology And Immunology National Defense Medical College
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Yoshizawa Nobuyuki
Department Of Electrical And Electronic Engineering Nippon Institute Of Technology
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WAKABAYASHI Kazuo
Department of Pathology (I), Juntendo University School of Medicine
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Yoshizawa Nobuyuki
Department of Chemistry, Faculty of Engineering Science, Osaka University
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