EFFECTS OF 6-MERCAPTOPURINE ON CYST DEVELOPMENT IN EXPERIMENTAL TOXOPLASMOSIS
スポンサーリンク
概要
- 論文の詳細を見る
The administration of the purine antagonist 6-MP greatly alters the course of a Toxoplasma infection in mice. The pathogenesis of the disease, in terms of morbidity and mortality, is much more severe; cyst production occurs in greater numbers, and possibly somewhat earlier than in normal mice; many cysts are found gathered in clusters; and the mice do not develop an effective immunity against a challenge with the virulent RH strain. A consideration of the pathological and serological findings in the 6MP-treated mice suggests that suppression of the immune response to Toxoplasma was achieved, and that as a result of this suppression, the various changes in the course of the infection occurred. The host immune response, therefore, does not appear to be a prerequisite to the formation and development of the Toxoplasma cyst.
- The Keio Journal of Medicineの論文
著者
-
Stahl Walter
Department Of Infectious Diseases Tokai University School Of Medicine
-
Akao Shinkichi
Department Of Parasitology And Immunology National Defense Medical College
-
MATSUBAYASHI HISAKICHI
Department of Parasitology, School of Medicine Keio University
-
AKAO SHINKICHI
Department of Parasitology, School of Medicine Keio University
-
STAHL WALTER
Department of Parasitology, School of Medicine Keio University
関連論文
- Morphology of Toxoplasma Tachyzoites in the Brain of an AIDS Patient
- MULTIPLE ORGAN DYSFUNCTION IN CONGENITAL MURINE TOXOPLASMOSIS
- A Single intradermal administration of soluble leishmanial antigen and plasmid expressing interleukin-12 protects BALB/c mice from Leishmania major infection
- Mice Lacking Protein Tyrosine Kinase Fyn Develop a T Helper-Type 1 Response and Resist Leishmania major Infection
- Cerebral Anomalies in Congenital Murine Toxoplasmosis : A Preliminary Report
- EFFECTS OF SPIRAMYCINE ON EXPERIMENTAL TOXOPLASMOSIS IN MICE
- COMPARATIVE STUDIES ON THE GROWTH OF HIGH AND LOW VIRULENT STRAINS OF TOXOPLASMA GONDII, WITH SPECIAL REFERENCE TO THE PRODUCTION OF CYST
- EFFECTS OF 6-MERCAPTOPURINE ON CYST DEVELOPMENT IN EXPERIMENTAL TOXOPLASMOSIS
- EXPERIMENTAL TOXOPLASMOSIS: EFFECTS OF SUPPRESSION OF THE IMMUNE RESPONSE OF MICE BY CORTISONE AND SPLENECTOMY
- IMMUNITY IN EXPERIMENTAL TOXOPLASMOSIS
- EXPERIMENTAL TRANSMISSION OF TOXOPLASMA GONDII IN MICE
- TREATMENT OF AMOEBIASIS WITH SPECIAL REFERENCE TO THE LOCALIZATION OF THE CAUSATIVE ORGANISM