IMMUNITY IN EXPERIMENTAL TOXOPLASMOSIS

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概要

• 論文の詳細を見る

• 1) Prior infection of mice with the low-virulence Beverley strain of Toxoplasma, after a period of 3 weks or more, protected mice against an otherwise lethal challenge with the highly virulent RH strain.<BR>2) The "immune" mice exhibited only a slight and transient loss of weight following exposure to RH, and after a week's time, commonly developed ascites, but otherwise remained in good condition. In contrast, the nonimmune mice suffered a sharp and sustained loss of weight, symptoms of severe disease, and death within 5 days.<BR>3) Chronically infected mice (Beverley for more than 5 months) on occasion reacted violently to challenge with RH, with the rapidity and nature of the reaction suggesting hypersensitivity.<BR>4) Briefly discussed are the participation of humoral factors in the acquired immunity, and the persistence of RH trophozoites in the peritoneal exudate of immune mice.

• The Keio Journal of Medicineの論文

著者

• Stahl Walter

  Department Of Infectious Diseases Tokai University School Of Medicine

• Akao Shinkichi

  Department Of Parasitology And Immunology National Defense Medical College

• STAHL WALTER

  Department of Parasitology, School of Medicine, Keio University

• AKAO SHINKICHI

  Department of Parasitology, School of Medicine, Keio University

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