The Formation of g = 2.49-Species of Cytochrome P450 in the Rat Liver by PCB126 Oral Administration : Identification of Heme Axial Ligands by EPR Spectroscopy
スポンサーリンク
概要
- 論文の詳細を見る
Rat livers and microsomes were subjected to electron paramagnetic resonance (EPR) measurements at 77 K. The EPR spectra of the livers from the control group, carbon tetrachloride-, 3-methylcholanthrene-, and 3,3′,4,4′,5-pentachlorobiphenyl (PCB126)-treated rats exhibited an EPR spectrum at g=2.40, 2.24, and 1.93, which is characteristic of P450 in a resting state. The liver of the PCB126-treated rats showed an additional distinct EPR spectrum at g=2.49, 2.26, and 1.87 (g=2.49-species). The heme environmental structure of g=2.49-species was identified by crystal field analysis using three EPR g-values of the microsome treated with various chemicals. These results indicated that g=2.49-species is a hemeprotein with cysteine thiolate at the 5th coordination site, and a nitrogenous ligand at the 6th site.
- 社団法人 日本農芸化学会の論文
- 2006-12-23
著者
-
MORITA Hidetoshi
Graduate School of Veterinary Medicine, Azabu University
-
TAKIZAWA Tatsuya
School of Veterinary Medicine, Azabu University
-
Akahori F
School Of Veterinary Medicine Azabu University
-
Akahori Fumiaki
麻布大学 獣医学部実験動物学
-
Akahori Fumiaki
Department Of Veterinary Pharmacology School Of Veterinary Medicine Azabu University Sagamihara
-
Akahori Fumiaki
School Of Veterinary Medicine Azabu University
-
Morita Hidetoshi
School Of Veterinary Medicine Azabu University
-
Shirai Mitsuyuki
School Of Veterinary Medicine Azabu University
-
YOSHIKAWA Hiroshi
School of Veterinary Medicine, Azabu University
-
Yoshimura Tetsuhiko
High-tech Research Center Azabu University
-
Takizawa Tatsuya
School Of Veterinary Medicine Azabu University
-
Morita Hidetoshi
Graduate School Of Veterinary Medicine Azabu University
-
Yoshikawa H
Graduate School Of Veterinary Medicine Azabu University
-
Morita Hidetoshi
School Of Veterinary Medicine Azabu Univ.
関連論文
- Nitric Oxide Production and Its Contribution to Hepatocyte Proliferation in Normal Juvenile Rats
- EFFECTS OF MATERNAL EXPOSURE TO A LOW DOSE OF DIETHYLSTILBESTROL ON SEXUAL DIMORPHIC NUCLEUS VOLUME AND MALE REPRODUCTIVE SYSTEM IN RAT OFFSPRING
- Effects of Maternal Exposure to Low Doses of DES on Testicular Steroidogenesis and Spermatogenesis in Male Rat Offspring
- Chymase is Activated in the Pulmonary Inflammation and Fibrosis Induced by Paraquat in Hamsters
- Mitochondrial diversity of native pigs in the mainland South and South-east Asian countries and its relationships between local wild boars
- A CALCIUM CHANNEL BLOCKER VERAPAMIL INHIBITS THE SPONTANEOUS CLOSURE OF THE DUCTUS ARTERIOSUS IN NEWBORN RATS
- The novel polymorphism of the beta 3-adrenergic receptor gene and its distribution in domestic pigs and wild boars in Asia
- STUDY ON CIRCARDIAN AND DAY TO DAY VARIATION OF SVPCs AND THE EFFECT OF EXERCISE ON THE FREQUENCY OF SVPCs : Arrhythmias (I) : FREE COMMUNICATIONS (II) : PROCEEDINGS OF THE 49th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- -1032-COMPARISON OF SENSITIVITY OF 2-LEAD HOLTER ECG IN THE DETECTION OF ISCHEMICST DEPRESSIONS BETWEEN DAILY ACTIVITY AND EXERCISE TESTING : THE 54th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- Therapeutic Effectiveness and Plasma Levels of Single or Combination Use of Class I Antiarrhythmic Agents for Ventricular Arrhythmias : SYMPOSIUM ON HIGH RISK ARRHYTHMIA ITS MECHANISM AND TREATMENT : 51th Annual Scientific Session of the Japanese Circulat
- -53- COMPARISON OF THE PROGNOSIS OF VEN-TRICULAR TACHYCARDIA BETWEEN PATIENTS WITH AND WITHOUT ORGANIC HEART DISEASE : Arrhythmias : FREE COMMUNICATIONS(I) : PROCEEDINGS OF THE 51th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- AN INNOVATIVE TECHNIQUE FOR RECORDING A 3-LEAD ELECTROCARDIOGRAM USING A 2-CHANNEL HOLTER RECORDER : Electrocardiography : PROCEEDINGS OF THE 50th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- Corticosterone Synthesis Inhibitor-Induced Decrease in the Age-Dependant Expression of Nitric Oxide Synthase 3 in the Preterm Ductus Arteriosus of Rats
- HISTOMETRIC CHANGES IN CONNECTIVE FIBERS OF THE LUNG FOLLOWING PARAQUAT ADMINISTRATION IN RATS
- HISTOMETRIC CHANGES IN CONNECTIVE FIBERS OF THE LUNG FOLLOWING PARAQUAT ADMINISTRATION IN RATS
- B-15 Effects of paraquat on mortality, serum ceruloplasmin, serum angiotensin I converting enzyme and lung hydroxyproline in rats pretreated with small dosage of paraquat and chlorpromazine
- B07 PARAQUAT TOXICITY OF SKIN INCISIONS IN RABBITS
- TRITOQUALINE AND PARAQUAT POISONING
- EFFECT OF PARAQUAT ON PLASMA FIBRONECTIN, SERUM FREE HYDROXYPROLINE, SERUM CERULOPLASMIN AND LUNG COLLAGEN CONTENT IN MONKEYS
- INHIBITION OF COLLAGEN SYNTHESIS, DEHYDROPROLINE AND PARAQUAT-INDUCED PULMONARY FIBROSIS
- "P-11 Constrictive Effects of indomethacin, Paraquat and Diquat on the Ductus Arteriosus in Fetal Rats.
- CONSTRICTIVE EFFECTS OF PARAQUAT ON THE DUCTUS ARTERIOSUS IN FETAL RATS
- CONSTRICTIVE EFFECTS OF PARAQUAT ON THE DUCTUS ARTERIOSUS IN FETAL RATS
- An Improved DNA Isolation Method for Metagenomic Analysis of the Microbial Flora of the Human Intestine
- Effect of oral administration of 3,3',4,4',5-pentachlorobiphyenl on the intestinal microbiota of Sprague-Dawley rats
- BIPYRIDYLIUM HERBICIDE AND DUCTUS ARTERIOSUS II
- BIPYRIDYLIUM HERBICIDE AND DUCTUS ARTERIOSUS I
- 2A-10 EFFECTS OF P=S TYPE ORGANOPHOSPHORUS INSECTICIDES ON THE FETAL DUCTUS ARTERIOSUS IN THE RAT
- INHIBITORY EFFECT OF INDOMETHACIN ON NEONATAL LUNG CATABOLISM OF PROSTAGLANDIN E_2: POSSIBLE MECHANISM OF THE RE-OPENING OF THE DUCTUS ARTERIOSUS AFTER INDOMETHACIN THERAPY
- 205 Effects of Azamethiphos, an Organophosphorus Insecticide, on the Serum Cholinestrase Activity and Isoenzymes in the Rat
- QUANTIFIABLE MORPHOLOGIC EVALUATION OF PARAQUAT PULMONARY TOXICITY IN RATS
- Gestational Changes in Production of NO and Expression of NOS mRNA Isoforms in the Rat Placenta
- Changes in Nitric Oxide Production Levels and Expression of Nitric Oxide Synthase Isoforms in the Rat Uterus during Pregnancy
- Identification of 3-Phenyllactic Acid As a Possible Antibacterial Substance Produced by Enterococcus faecalis TH10
- Anti-microbial Action against Verotoxigenic Escherichia coli O157:H7 of Nitric Oxide Derived from Sodium Nitrite
- P10-04 Changes Detected in Plasma Antiproteases in Paraquat Poisoned Rats Using Micro Two-Dimensional Electrophoretic Analysis
- Evaluation of Antiarrhythmic Drug Efficacy using Holter Electrocardiographic Technique : SYMPOSIUM ON INDICATION AND SELECTION OF ANTIARRHYTHMIC TREATMENT
- Purification and Properties of Membrane-bound Sulfite Dehydrogenase from Thiobacillus thiooxidans JCM7814
- Aqueous Extracts of Rhizopus oryzae Induce Apoptosis in Human Promyelocytic Leukemia Cell Line HL-60
- Potency of Water Extracts of Rhizopus oryzae on the Salmonella Infection Rat
- Electron paramagnetic resonance analysis of liver and serum in Sprague-Dawley rats exposed subchronically to coplanar pentachlorobiphenyl-congener 3,3',4,4',5
- 3C-04 The Protection against to Testicular Cadmium Toxicity and Induction of Metallothionein-Like Cadmium Binding Protein in the Testis
- Induction of Metallothionein-Like Cadmium-Binding Protein in the Testis by Oral Cadmium Administration in Rats
- Effects of Long-Term Cadmium Intake on Renal Function and Bone Mineral Density (Proceedings of the 20th Symposium on Toxicology and Environmental Health)
- Effects of Maternal Exposure to Diethylstilbestrol on Epididymal Development in Rat Offspring(Anatomy)
- EFFECTS OF MATERNAL EXPOSURE TO DIETHYLSTILBESTROL ON THE DEVELOPMENT OF THE REPRODUCTIVE SYSTEM AND THYROID FUNCTION IN MALE AND FEMALE RAT OFFSPRING
- Lack of Constrictive Effects of Cocaine on the Fetal Ductus Arteriosus in the Rat
- Co-planar PCBs, biotoxicants (PRESIDENTIAL LECTURE) (Proceedings of the 30th Annual Meeting)
- Changes in Nitric Oxide Production Levels and Expression of Nitric Oxide Synthase Isoforms in the Rat Uterus during Pregnancy
- Paenibacillus macerans Possesses Two Types of 16S rDNA Copies in a Genome with a Length Difference of Twelve Base Pairs
- The Formation of g = 2.49-Species of Cytochrome P450 in the Rat Liver by PCB126 Oral Administration : Identification of Heme Axial Ligands by EPR Spectroscopy
- Purification and Properties of Thiosulfate Dehydrogenase from Acidithiobacillus thiooxidans JCM7814
- Lactobacillus hayakitensis, L. equigenerosi and L. equi, predominant lactobacilli in the intestinal flora of healthy thoroughbreds
- An insertion/deletion variant of a thymine base in exon 2 of the porcine beta 3-adrenergic receptor gene associated with loin eye muscle area
- Effect of D-Alanine in Teichoic Acid from the Streptococcus thermophilus Cell Wall on the Barrier-Protection of Intestinal Epithelial Cells
- Association of an SNP marker in exon 24 of a class 3 phosphoinositide-3-kinase (PIK3C3) gene with production traits in Duroc pigs
- Molecular phylogeny and diversity of Myanmar and Bhutan mithun based on mtDNA sequences
- Polymorphisms in the bovine hemoglobin-beta gene provide evidence for gene-flow between wild species of Bos (Bibos) and domestic cattle in Southeast Asia
- Aqueous Extracts of Rhizopus oryzae Induced Nitric Oxide Production in Rat Hepatocyte Cell Line RLN-10
- Nitric Oxide Induces Vascular Endothelial Growth Factor Expression in the Rat Placenta in Vivo and in Vitro
- A queous Extras of Rhizopus oryzae Induced Nitric Oxide Production in Rat Hepatocyte Cell Line RLN-10
- Excretion of 3,3',4,4',5-Pentachlorobiphenyl (PCB126) from Rat Liver Following Oral Administration of Lactobacillus reuteri and Lactobacillus acidophilus