EFFECTS OF BRAIN BIOGENIC AMINES ON ETHANOL WITHDRAWAL REACTIONS AND THE DEVELOPMENT OF ETHANOL DEPENDENCE IN MICE
スポンサーリンク
概要
- 論文の詳細を見る
Mice were made physically dependent on ethanol by a four-day period of ethanol inhalation. A single injection of L-dopa tended to enhance ethanol withdrawal reactions and 5HTP tended to suppress it. Daily treatment with PCPA and L-dopa or pretreatment with 60HDA tended to modify the severity of withdrawal reactions. PCPA slightly decreased the severity, 60HDA tended to aggravate the severity, and L-dopa tended to decrease the severity. The simultaneous estimation of brain biogenic amine levels suggests that 5HT and DA may be involved in the development of physical dependence on ethanol. Treatment with neuropharmacological drugs during ethanol withdrawal modified the severity of ethanol withdrawal reactions. Pentobarbital and diazepam completely suppressed ethanol withdrawal reactions. GHBA and reserpine suppressed the severity and haloperidol, imipramine, and methylphenidate aggravated it. The simultaneous estimation of brain catecholamine levels suggests that suppression of ethanol withdrawal reactions consistently results from the decreased activities of either noradrenergic or dopaminergic neurons. However, the effects of biogenic amines on ethanol withdrawal reactions may be different from those on the development of physical dependence on ethanol.
- 社団法人 日本薬理学会の論文
著者
関連論文
- INITIAL METABOLISM OF GAMMA-HEXACHLOROCYCLOHEXANE (γ-HCH) BY RAT LIVER MICROSONES
- Protective Effect of Ninjin-yoei-to on Damage to Isolated Hepatocytes Following Transient Exposure to tert-Butly Hydroperoxide
- O-43 Study of environmental chemicals on central nervous system : Styrene inhibits monoamine oxidase activity in monkey brain, in vitro.(Proceedings of the 27th Annual Meeting)
- Day/Night Variation of 5-Hydroxyindole Acetic Acid Concentration in Rat Cerebrospinal Fluid After Acute and Long-Term Administration of a Selective Serotonin Reuptake Inhibitor, Fluvoxamine
- The Inhibition of Monoamine Oxidase Activity by Various Antidepressants: Differences Found in Various Mammalian Species
- Monitoring of Radical Scavenging Activity of Peroral Administration of the Kampo Medicine Sho-saiko-to in Rats
- Variation of Monoamines and Their Metabolite Contents in the Cerebrospinal Fluid of Conscious Rats
- "P-17 NO contribution to lipopolysaccharide-induced hepatic damage of galactosamine-sensitized mice.
- Effects of Bifemelane on Muscarinic Receptors and Choline Acetyltransferase in the Brains of Aged Rats Following Chronic Cerebral Hypoperfusion Induced by Permanent Occlusion of Bilateral Carotid Arteries
- Effect of Fluvoxamine on 5-Hydroxytryptamine Uptake, Paroxetine Binding Sites and Ketanserin Binding Sites in the Japanese Monkey Brain and Platelets, In Vivo and In Vitro
- Role of oxygen-derived free radicals and lipid peroxidation in blood induced by lipopolysaccharide(LPS).
- THE MULTIPLE HYDROPEROXIDES OF CHOLINE PHOSPHOLIPIDS OCCURRING IN PLASMA AFTER ISCHEMIA-REPERFUSION IN RAT LIVER
- Idenitification of phospholipid hydroperoxides in plasma of hepatic ischemiareperfused rats
- W-4 Investigation of the Other Organ Injury Caused by Liver Ischemia-Reperfusion
- IN VIVO GENERATION OF HYDROXYL FREE RADICALS IN JEJUNAL ISCHEMIA-REPERFUSION INJURY
- Effect of Long-Term Fluvoxamine Treatment on Endogenous Serotonin Uptake Inhibitor-Like Substance in Monkey Cerebrospinal Fluid
- METHAMPHETAMINE-INDUCED BEHAVIORAL EFFECTS AND RELEASES OF BRAIN CATECHOLAMINES AND BRAIN CONCENTRATIONS OF METHAMPHETAMINE IN MICE
- EFFECTS OF CEPHEM ANTIBIOTICS ON RAT LIVER ALDEHYDE DEHYDROGENASES
- NADPH-DEPENDENT LIPID PEROXIDATION IN THE LIVER MICROSOME OF RATS FED A 3-METHYL-4-DIMETHYL-AMINOAZOBENZENE (3-Me-DAB)-CONTAINING DIET
- Effect of Methylprednisolone on Plasma Lipid Peroxidation Induced by Lipopolysaccharide
- SUPPRESSIVE EFFECT OF BIFEMELANE ON LIPID PEROXIDATION IN RAT LIVER
- 308 INVESTIGATION OF THE OTHER ORGANIC INJURIES CAUSED BY LIVER ISCHEMIA-REPERFUSION
- A06 SUPPRESSIVE EFFECT OF BIFEMELANE ON LIPID PEROXIDATION IN RAT LIVER
- B23 EFFECTS OF BIFEMELANE ON LIPID PEROXEDATION IN RAT LIVER
- NO CONTRIBUTION TO LIPOPOLYSACCHARIDE-INDUCED HEPATIC DAMAGE IN GALACTOSAMINE-SENSITIZED MICE
- EFFECT OF SALSOLINOL ON RAT BRAIN AND LIVER MONOAMINE OXIDASE
- "A-1 Hydroxyl free radical generation by monoamine oxidase inhibitor in rat myocardium.
- EFFECTS OF ETHANOL ON CATECHOLAMINE LEVELS AND RELATED ENZYME ACTIVITIES IN DIFFERENT BRAIN REGIONS OF RATS
- FURTHER STUDIES ON THE SYNTHESIS OF A-FORM MONOAMINE OXIDASE
- Protective Effect of Histidine on Hydroxyl Radical Generation Induced by Potassium-Depolarization in Rat Myocardium
- 2C-18 Oxidative biomembrane destruction with ensuing cell rupture associated with free radical species generation
- EFFECTS OF BRAIN BIOGENIC AMINES ON ETHANOL WITHDRAWAL REACTIONS AND THE DEVELOPMENT OF ETHANOL DEPENDENCE IN MICE
- BRAIN SEROTONIN TURNOVER IN ALCOHOLIC MICE
- Attenuation of Dysfunction in the Ischemia-Reperfused Liver by Glycyrrhizin
- Characteristics of Mitochondrial and Synaptosomal Monoamine Oxidase in Monkey Brain
- Some Interrelated Properties of A and B Form Monoamine Oxidase in Monkey Brain Mitochondria
- Effects of d-methamphetamine on monkey brain monoamine oxidase, in vivo and in vitro.
- Changes in amine oxidase in plasma of rats treated with hepatotoxins.
- Effect of bifemelane hydrochloride on an injury of the liver caused by ischemia-reperfusion in rats.
- Changes in MAO activities in several organs of rats after administration of l-thyroxine.