Surfactant Protein-A Concentration in Sera from Dogs with Pulmonary Parenchymal Diseases
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概要
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Pulmonary surfactant protein A (SP-A) is used as a biomarker to understand the clinical features of pulmonary diseases and associated prognostic indices in human medicine. This study was conducted to investigate whether or not serum SP-A concentration can be used as a biomarker for identifying pulmonary parenchymal diseases in dogs. Thirty-two dogs with pulmonary parenchymal diseases, 34 with nonrespiratory diseases and 57 healthy dogs were included. Serum SP-A concentration was measured in all dogs using sandwich enzyme linked immunosorbent assay with an anti-dog SP-A polyclonal antibody. Median serum SP-A concentration in healthy dogs was <2.0 ng/ml, whereas that in dogs with aspiration pneumonia (n=11), primary lung tumors (n=9) and blunt traumatic lung injury (BTLI; n=12) was 3.1, 7.2 and 2.6 ng/ml, respectively; these values were significantly higher than those in healthy dogs. The serum SP-A concentration in dogs with nonrespiratory diseases was comparable with that in healthy dogs. No correlation was observed between the serum SP-A and plasma C-reactive protein concentrations in dogs with aspiration pneumonia and BTLI. There was a significant correlation between the serum SP-A concentration and thoracic radiographic changes in dogs with BTLI. These findings suggest that the serum SP-A concentration may be a useful clinical biomarker of alveolar damage that can be used for differential diagnosis of pulmonary parenchymal diseases and nonrespiratory diseases in dogs.
- 公益社団法人 日本獣医学会の論文
著者
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Akiyoshi Hideo
Department Of Biological Science Faculty Of Life And Enviromemtal Science Shimane University
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SUGII Shunji
Department of Serology and Immunology, School of Medical Technology, Kitasato University
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Ohashi Fumihito
Department Of Veterinary Surgery College Of Agriculture Osaka Prefecture University
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Tanaka Toshiyuki
Department Of Applied Chemistry Faculty Of Engineering University Of Toyama
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SHIMIZU Junichiro
Department of Clinical Veterinary Science, Obihiro University of Agriculture and Veterinary Medicine
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TANAKA Toshiyuki
Department of Veterinary Clinical Sciences, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, 1–58 Rinku-ohrai-kita, Izumisano, Osaka 598–8531, Japan
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SONE Katsuhito
Department of Veterinary Clinical Sciences, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, 1–58 Rinku-ohrai-kita, Izumisano, Osaka 598–8531, Japan
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CAO Zheng
Department of Veterinary Clinical Sciences, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, 1–58 Rinku-ohrai-kita, Izumisano, Osaka 598–8531, Japan
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LI Yijyun
Department of Veterinary Clinical Sciences, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, 1–58 Rinku-ohrai-kita, Izumisano, Osaka 598–8531, Japan
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HAYASHI Akiyoshi
Department of Veterinary Clinical Sciences, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, 1–58 Rinku-ohrai-kita, Izumisano, Osaka 598–8531, Japan
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SHIMIZU Junichiro
Department of Veterinary Clinical Sciences, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, 1–58 Rinku-ohrai-kita, Izumisano, Osaka 598–8531, Japan
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SHIMIZU Junichiro
Department of Applied Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine
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