Analysis of the Epitopes on Staphylococcal Enterotoxin A Responsible for Emetic Activity.
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概要
- 論文の詳細を見る
To identify which region of staphylococcal enterotoxin A (SEA) is responsible for the emetic activity, twelve synthetic peptides corresponding to the entire SEA amino acid sequence and their respective anti-peptide antibodies were prepared and tested. The anti-peptide antibodies were tested for neutralization of SEA-induced emesis in Suncus murinus (Shrew mouse). The results indicate that SEA-induced emesis was neutralized by the mixture of three anti-peptide antibodies to A-7 (corresponding to amino acid residues 121-140), A-8 (141-160) and A-9 (160-180). These findings suggest that the regions corresponding to residues 121-180 may be the epitopes responsible for the emetic activity of SEA.
- 公益社団法人 日本獣医学会の論文
著者
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Nakane Akio
Department Of Bacteriology Hirosaki University School Of Medicine
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SUGII Shunji
Department of Serology and Immunology, School of Medical Technology, Kitasato University
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SALEH Mona
)Department of Veterinary Microbiology, Faculty of Agriculture, Iwate University
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NAKANE Akio
Department of Biotechnology, Hiroshima University School of Medicine
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SHINAGAWA Kunihiro
)Department of Veterinary Microbiology, Faculty of Agriculture, Iwate University
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OMOE Katsuhiko
)Department of Veterinary Microbiology, Faculty of Agriculture, Iwate University
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HU Dong-Liang
)Department of Veterinary Microbiology, Faculty of Agriculture, Iwate University
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ONO Katsuhiko
)Department of Veterinary Microbiology, Faculty of Agriculture, Iwate University
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