＜Poster＞Mouse peptidoglycan recognition protein（ PGRP）-S : the role in bacterial infection
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概要
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Peptidoglycan recognition proteins （PGRPs） are pattern recognition receptors which are conserved frominsects to humans. PGRPs can recognize bacteria and their cell wall components, peptidoglycans. Human PGRPs havebactericidal activities that can be accomplished by their amidase activities. Insect PGRPs consist of 16 subtypes andsome have eff ector functions as the activation of Toll pathway （PGRP-SA）, the activation of Imd pathway （PGRPLC）and induction of autophagosome formation （PGRP-LE）, thus contribute to the elimination of bacteria. However,the role of mammalian PGRPs in bacterial infection remains unclear. In this study, we report the function of mousePGRP-S, the homologue of PGRP-SA, in bacterial infection. The recombinant protein was produced in Escherichiacoli overexpression system and used for specifi c antibody production. We investigated the role of PGRP-S in infectionwith Listeria monocytogenes, a facultative Gram-positive bacterium that can grow intracellularly. The administrationof recombinant PGRP-S before L. monocytogenes infection decreased the number of bacteria in the organs of infectedmice. When endogenous PGRP-S was neutralized by antibodies specifi c to PGRP-S, the bacterial number increased.The levels of proinfl ammatory cytokines that are essential in the protection against L. monocytogenes infection werelower when the specific antibody was administered prior to infection. Together with these, it is suggested thatPGRP-S plays a role in the protection against L. monocytogenes infection.
著者
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Nakane Akio
Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine
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Osanai Arihiro
Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine
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Li Sheng-Jun
Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine
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Nakane Akio
Department Of Microbiology And Immunology Hirosaki University Graduate School Of Medicine
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Li Sheng-jun
Department Of Microbiology And Immunology Hirosaki University Graduate School Of Medicine
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Osanai Arihiro
Department Of Microbiology And Immunology Hirosaki University Graduate School Of Medicine
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Nakane Akio
Department Of Bacteriology Hirosaki University School Of Medicine
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