Salmon cartilage proteoglycan modulates cytokine responses to Escherichia coli in mouse macrophages
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概要
- 論文の詳細を見る
Proteoglycans （PGs） are complex glycohydrates, which are widely distributed in connective tissues andon the cell surface of mammalian tissues. We investigated the effect of PG extracted from salmon cartilage oncytokine responses to stimulation with heat-killed Escherichia coli（ HKEC） in a mouse macrophage cell line, RAW264.7.PG exhibited the suppression of tumor necrosis factor（ TNF）-α production and enhancement of interleukin（ IL）-10production compared with chondroitin 4 sulfate（ C4S） and chondroitin 6 sulfate（ C6S）. PG, C4S and C6S suppressedHKEC-induced Toll-like receptor 4（ TLR4） and inducible nitric oxide synthase（ iNOS） expression dose-dependentlyand the PG showed the strongest suppressive effect among 3 compounds. Only PG dramatically up-regulated theexpression of signal transducers and activators of transcription 3（ STAT3） and the phosphorylation of STAT3 in mousemacrophages. Our results showed strong suppression of PG on infl ammatory response and suggested that the novelinteraction might exist between the extracellular matrix and immune system.
- 弘前大学の論文
著者
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Sashinami Hiroshi
Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine
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Nakane Akio
Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine
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Sashinami Hiroshi
Department Of Microbiology And Immunology Hirosaki University Graduate School Of Medicine
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Nakane Akio
Department Of Microbiology And Immunology Hirosaki University Graduate School Of Medicine
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Nakane Akio
Department Of Bacteriology Hirosaki University School Of Medicine
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Takagaki Keiichi
Department of Glycotechnology, Hirosaki University Graduate School of Medicine
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Takagaki Keiichi
Department Of Glycotechnology Hirosaki University Graduate School Of Medicine
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Takagaki Keiichi
Department Of Biochemistry And Molecular Biology Pennsylvania State University College Of Medicine
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