＜Poster＞Immunization with nontoxic mutant staphylococcal enterotoxin a protects against enterotoxin-induced emesis in house musk shrews
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概要
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We investigated the eff ect of p60 that is one of virulence factors of Listeria monocytogenes on host immuneresponse in vitro and in vivo. C57BL/6 mice immunized with p60 showed antigen-specifi c T-helper I type immuneresponse. Mouse macrophage RAW264.7 cells produced tumor necrosis factor alpha （TNF-α）, interleukin-12 andinterferon beta （IFN-β） in response to stimulation with recombinant p60. Administration of p60 prior to a sublethalinfection with L. monocytogenes enhanced innate host resistance in naïve mice. TNF-α and IFN-β production fromRAW264.7 cells and bone marrow-derived macrophages were Toll-like receptor 4 （TLR4）-dependent. The enhancedclearance of L. monocytogenes by p60 administration was not shown in C3H/HeJ mice. Our fi ndings demonstrated thatp60 enhances host resistance against L. monocytngenes infection through both activation and attenuation of host innateimmune response in the TLR4-dependent manner.
著者
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Nakane Akio
Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine
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Sashinami Hiroshi
Department Of Microbiology And Immunology Hirosaki University Graduate School Of Medicine
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Sashinami Hiroshi
弘前大学医学部附属脳神経血管病態研究施設 脳血管病態学
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Li Sheng-Jun
Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine
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HU Dong-Liang
Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine
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Hakamada Kenichi
Department Of Gastroenterological Surgery Hirosaki University Graduate School Of Medicine
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Nakane Akio
Department Of Microbiology And Immunology Hirosaki University Graduate School Of Medicine
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Li Sheng-jun
Department Of Microbiology And Immunology Hirosaki University Graduate School Of Medicine
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FUKUDA SHINSAKU
Department of Gastroenterology, Hirosaki University Hospital
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Nakane Akio
Department Of Bacteriology Hirosaki University School Of Medicine
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Mitsui Toshihito
Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine
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Hakamada Ken-ichi
Department of Digestive Surgery, Hirosaki University Graduate School of Medicine
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Ishiguro Yoh
Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine
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Fukuda Shinsaku
Department Of Endoscopy Hirosaki University School Of Medicine
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Fukuda Shinsaku
Department Of Gastroenterology And Hematology Hirosaki University Graduate School Of Medicine
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Hu Dong-liang
Department Of Microbiology And Immunology Hirosaki University Graduate School Of Medicine
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Ishiguro Yoh
Department Of Gastroenterology And Hematology Hirosaki University Graduate School Of Medicine
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Satoh Hisashi
Hirosaki Univ. Graduate School Of Medicine Hirosaki Jpn
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Hakamada Ken-ichi
Department Of Digestive Surgery Hirosaki University Graduate School Of Medicine
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Sakaki Hirotaka
Department Of Dentistry And Oral Surgery Hirosaki University School Of Medicine
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Mitsui Toshihito
Department Of Microbiology And Immunology Hirosaki University Graduate School Of Medicine
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Ishiguro Yo
Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine
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HAKAMADA Kenichi
Department of Digestive Surgery, Hirosaki University Graduate School of Medicine
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