＜Poster＞Cystatin C immunoreactivity and neuronal degeneration in amyotrophic lateral sclerosis
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概要
- 論文の詳細を見る
Background. Staphylococcal enterotoxins （SEs） are the most common cause of food-borne diseases andtoxic shock syndrome throughout the world. However, little is known about the mechanism of emesis induced by SEsand no vaccine that prevents SE-induced emesis has been described. Methods. A nontoxic mutant SEA, SEAD227A,was constructed by site-directed mutagenesis and purified from Escherichia coli expression system. House muskshrews, a small emetic animal model, were immunized with SEAD227A and then challenged with wild-type SEA.SEA-induced emesis was recorded for 3 h. Antibody production was analyzed by gel double-immunodiff usion assay.Neutralizing activities of the antibodies to superantigenic and emetic activities were analyzed in vitro and in vivo.Results. SEAD227A was devoid of both superantigenic and emetic activities, but still retained its immunologicalactivity. Immunization with SEAD227A strongly induced specifi c antibody production and signifi cantly provided theprotection against SEA-induced emesis. The antibodies from immunized shrews markedly inhibited the SEA-inducedproliferation of spleen cells and also significantly ablated the SEA-induced vomiting in the animals. Conclusions.These results suggest that vaccination with SEAD227A devoid of toxic properties provides protection against SEAinducedemesis. This nontoxic mutant and its specifi c antibodies might be useful in the prevention and treatment ofstaphylococcal food poisoning
- 弘前大学の論文
著者
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Nakane Akio
Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine
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Sashinami Hiroshi
Department Of Microbiology And Immunology Hirosaki University Graduate School Of Medicine
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Sashinami Hiroshi
弘前大学医学部附属脳神経血管病態研究施設 脳血管病態学
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HU Dong-Liang
Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine
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Nakane Akio
Department Of Microbiology And Immunology Hirosaki University Graduate School Of Medicine
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Nakane Akio
Department Of Bacteriology Hirosaki University School Of Medicine
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Omoe Katsuhiko
Department of Veterinary Microbiology, Faculty of Agriculture, Iwate University
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Shinagawa Kunihiro
Department of Veterinary Microbiology, Faculty of Agriculture, Iwate University
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Hu Dong-liang
Department Of Microbiology And Immunology Hirosaki University Graduate School Of Medicine
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Satoh Hisashi
Hirosaki Univ. Graduate School Of Medicine Hirosaki Jpn
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Omoe Katsuhiko
Department Of Veterinary Microbiology Faculty Of Agriculture Iwate University
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Shinagawa Kunihiro
Department Of Veterinary Medicine Iwate University
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Shinagawa Kunihiro
Department Of Veterinary Microbiology Faculty Of Agriculture Iwate University
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Omoe Katsuhiko
Department Of Veterinary Medicine Faculty Of Agriculture Iwate University
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Shinagawa Kunihiro
Department Of Veterinary Medicine Faculty Of Agriculture Iwate University
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Sakaki Hirotaka
Department Of Dentistry And Oral Surgery Hirosaki University School Of Medicine
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