Studies on Inhibition of Enzymatic Arginyltransfer Reaction

スポンサーリンク

概要

• 論文の詳細を見る

• Synthetic polyamines and various derivatives of aspartic acid and glutamic acid were examined in vitro for their inhibitory activity on arginyl-tRNA-protein transferase. All the polyamines tested showed non-specific activation or inhibition at 0.1 or 10 mM, respectively, suggesting an interaction of polyamines with tRNA. Of the newly prepared active site directed compounds including the inhibitory peptides so far reported, L-aspartic acid α-[(S)-(-)-naphthylethylamide] was found to inhibit the enzyme activity most potently with a slight substrate activity, whereas the R-isomer showed very weak inhibition, giving information on the active site of the enzyme.

• 公益社団法人日本薬学会の論文
• 1998-07-15

著者

• TAKAO Koichi

  Faculty of Pharmaceutical Sciences, Josai University

• SHIRAHATA Akira

  Faculty of Pharmaceutical Sciences, Josai University

• SAMEJIMA Keijiro

  Faculty of Pharmaceutical Sciences, Josai University

• Shirahata Akira

  産業医科大学 医学部小児科学

• Shirahata A

  Fac. Of Pharmaceutical Sciences Josai Univ.

• Shirahata A

  聖マリアンナ医科大学 医学部医学統計学分野

• Shirahata Akira

  Univ. Occupational And Environmental Health Kitakyushu Jpn

• Shirahata Akira

  Faculty Of Pharmaceutical Science Josai University

• Takao Koichi

  Faculty Of Pharmaceutical Sciences Josai University

• Samejima Keijiro

  Faculty Of Pharmaceutical Sciences Josai University

• Samejima K

  Faculty Of Pharmaceutical Sciences Josai University

• Takao K

  Faculty Of Pharmaceutical Sciences Josai University

• 鮫島 啓二郎

  Faculty Of Pharmaceutical Sciences Josai University

• IGARASHI Toshihisa

  Faculty of Pharmaceutical Sciences, Josai University

• OGISO Hironao

  Faculty of Pharmaceutical Sciences, Josai University

• UGATA Kazuya

  Faculty of Pharmaceutical Sciences, Josai University

• Ugata Kazuya

  Faculty Of Pharmaceutical Sciences Josai University

• Ogiso Hironao

  Faculty Of Pharmaceutical Sciences Josai University

• Shirahata Akira

  Lab. Of Cellular Physiology Dep. Of Clinical Dietetics And Human Nutrition Fac. Of Pharmaceutical Sc

• Igarashi T

  Faculty Of Pharmaceutical Sciences Josai University

関連論文

• Assay of N1-Acetylpolyamine Oxidase Activity with N1,N11-Didansylnorspermine as the Substrate by Ion-Pair Reversed Phase High Performance Liquid Chromatography
• Formation of Spermidine or Norspermidine from Synthetic Diacetylpolyamines by Acetylpolyamine Oxidase in Cultured Cells(Biochemistry)
• A New Ultra-micro Microbioassay
• Current status of Japanese HIV-infected patients with coagulation disorders : coinfection with both HIV and HCV
• Consensus Guideline for Diagnosis and Treatment of Childhood Idiopathic Thrombocytopenic Purpura
• The Number of People in Japan with Coagulation Disorders : 2001 Update
• Clinical Trial to Investigate the Pharmacokinetics, Pharmacodynamics, Safety, and Efficacy of Recombinant Factor VIIa in Japanese Patients With Hemophilia With Inhibitors
• A Prospective, Randomized Trial of Conventional, Dose-Accelerated Contricosteroids and Intravenous Immunoglobulin in Children With Newly Diagnosed Idiopathic Thrombocytopenic Purpura
• Observed Decline in the Rate of Death Among Japanese Hemophiliacs Infected With HIV-1
• Pharmacolinetics, Prophylactic Effects, and Safety of a New Recombinant FVIII Formulated with Sucrose (BAY 14-2222) in Japanese Patients with Hemophilia A
• Cumulative Fraction of Patients with AIDS among Japanese Hemophiliacs Infected with HIV-1
• Increases in DNA and Protein Syntheses in Human Umbilical Vein Endothelial Cells Treated with Asbestos
• Increases of thrombomodulin activity and antigen level on human umbilical vein endothelial cells treated with asbestos and man-made mineral fibers
• Simultaneous Determination of Endogenous and Orally Administered 15N-Labeled Polyamines in Rat Organs
• Syntheses of [13C, 15N]-Labeled Polyamines
• Regulation of estrogenic and nuclear factor κB functions by polyamines and their role in polyamineanalog-induced apoptosis of breast cancer cells
• Antitumor effect of bis(ethyl)polyamine analogs on mammarytumor development in FVB /NTgN (MMTVneu) transgenic mice
• Fate of Orally Administered 15N-Labeled Polyamines in Rats Bearing Solid Tumors
• Measurements of Macromolecule-Bound and Ultra-FiltrablePolyamines in Rat Liver Homogenized without Buffer
• Preparation and Usefulness of Some Fluorogenic Substrates for Assay of Arginyl-tRNA-Protein Transferase byHPLC
• Fluorometric Determination of 1,2,3,4-Tetrahydro-6,7-dihydroxyisoquinoline in Biological Materials by HPLC
• Syntheses of [5,8-^C_2]- and [1,12-C_2]Spermine Using Potassium [^C]Cyanide as the ^C Source
• Synthetic Decarboxylated S-Adenosyl-L-methionine as a Substrate for Aminopropyl Transferases
• Mass Spectrometric Separation and Determination of N1,N12-Diacetylspermine in the Urine of Cancer Patients
• Conformational Stabilization of Rat S-Adenosylmethionine Decarboxylase by Putrescine
• Structural and Functional Relationship among Diamines in Terms of Inhibition of Cell Growth
• Polyamine Cytotoxicity in the Presence of Bovine SerumAmine Oxidase
• Inhibition of Cell Growth by Combination of α-Difluromethylornithine and an Inhibitor of Spermine Synthase
• A Molecular Beacon Strategy for ThermodynamicCharacterization of Triplex DNA : Triplex Formation atthe Promoter Region of Cyclin D1
• A Gas Chromatographic Determination Method of 5-Chloro-7-iodo-8-quinolinol and Its Conjugates in Biological Fluids
• Synthesis of 5-Chloro-7-iodo-8-quinolinol Sulfate
• Bifidus Factors in Carrot. I. Purification and Some Properties
• Inhibition of Putrescine Aminopropyltransferase Influences Rat Liver Regeneration(Analytical Biochemistry)
• Control of Spermidine and Spermine Levels in Rat Tissues by trans-4-Methylcyclohexylamine, a Spermidine-Synthase Inhibitor(Analytical Biochemistry)
• Mammalian Spermidine Synthase : Identification of Cysteine Residues and Investigation of the Putrescine Binding Site(Analytical Biochemistry)
• Synthetic Decarboxylated S-Adenosyl-L-methionine as a Substrate for Aminopropyl Transferases
• Fate of Orally Administered ^15N-LabeIed Polyamines in Rats Bearing Solid Tumors
• Measurements of Macromolecule-Bound and Ultra-Filtrable Polyamines in Rat Liver Homogenized without Buffer
• Primary Structure of Rat Spermidine Synthase : An Example of Refining the cDNA-Derived Amino Acid Sequence
• Determination of Covalently Bound Hypusine and Deoxyhypusine to Protein Using Submilligram of Protein Samples by HPLC
• Specific Depletion of Spermidine and Spermine in HTC Cells Treated with Inhibitors of Aminopropyltransferases^1
• Enzymatic Aminopropylation of Certain Secondary Amines
• A Simpler Synthesis of D-Pantothenic Acid 4'-Phosphate
• Primary Structure of Rat Spermidine Synthase: AnExample of Refining the cDNA-Derived Amino AcidSequence
• Antagonistic Effect of N - (3 - Aminopropyl)cyclohexylamine on Neurotrophic Action of Spermine in Primary Cultured Rat Hippocampal and Cerebellar Neurons
• Structural Requirement for Neurotrophic Activity of Spermine in Cultured Rat Hippocampal Neurons
• Prevalence of Hepatitis C Virus Infection in Coagulation Disorders in Japan
• Mass Spectrometric Separation and Determination of N^1,N^-Diacetylspermine in the Urine of Cancer Patients
• スペルミジン過剰蓄積細胞における核成分の変化
• Identification of the Primary Structure and Post-translational Modification of Rat S-Adenosylmethionine Decarboxylase
• Occurrence of aminopropylhomospermidine as themajor cellular polyamine in a halophilic, phototrophicalpha proteobacterium, Rhodothalassium salexigens
• Occurrence of tertiary branched tetraamines in two aquaticplants
• IDENTIFICATION OF N^4-(2-PROPENAL) SPERMIDINE AS A MAJOR REACTION PRODUCT OF MALONDIALDEHYDE AND SPERMIDINE
• Syntheses of Tertiary Tetraamines and Quaternary Pentaamines with Three and Four Methylene Chain Units
• Analayses of Variously ^N-Enriched Spermidines during Growth of Candida coidinii Cultured with ^N-Enriched Ammonium Sulfate and α-^N-Enriched L-Ornithine
• Syntheses of a Series of Linear Pentaamines with Three and Four Methylene Chain Intervals
• Studies on Inhibition of Enzymatic Arginyltransfer Reaction
• Arginyl-tRNA-Protein Transferase Activities in CrudeSupernatants of Rat Tissues
• ポリアミンの調節を目指した方法論の開発
• アスパラギン酸アナログによるアルギニルトランスフェラーゼの阻害効果の検討
• SYNTHESES AND ANALYSES OF TERTIARY AND QUATERNARY POLYAMINES
• SYNTHESES AND ANALYSES OF A SERIES OF LINEAR PENTAAMINES EXPECTED IN NATURAL SOURCES
• Effects of Dehydroepiandrosterone on Oleic Acid Formation in the Liver of Rats, Mice and Guinea Pigs
• Metabolism of 4-Dimethylaminoazobenzene and Related Compounds. III. Metabolites of 4-Dimethylaminoazobenzene in Rat Bile and Influence of DAB Feeding on their Amounts
• A Probable Structure of the Bifidus Factor in Carrot Root
• TRANS-4-METHYLCYCLOHEXYLAMINE, A POTENT NEW INHIBITOR OF SPERMIDINE SYNTHASE
• Metabolites of p-Dimethylaminoazobenzene in Rat Bile
• MICROBIOLOGICAL ULTRAMICRO DETERMINATION OF PANTOTHENIC ACID, BIOTIN, AND NICOTINIC ACID WITH AMPLIFIED CULTIVATION
• Metabolism of 4-Dimethylaminoazobenzene and Related Compounds. IV. Metabolites of o-Aminoazotoluene in Rat Bile.
• Pentamines as Substrate for Human Spermine Oxidase

もっと見る 閉じる

スポンサーリンク