TRANS-4-METHYLCYCLOHEXYLAMINE, A POTENT NEW INHIBITOR OF SPERMIDINE SYNTHASE
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概要
- 論文の詳細を見る
Trans-4-methylcyclohexylamine was found to inhibit pig spermidine synthase potently in assay conditions containing 50 μM of decarboxylated S-adenosylmethionine. It showed 50% inhibition at 1.7 μM compared to 8.1 μM for cyclohexylamine, and 2.5 μM for S-adenosyl-1,8-diamino-3-thiooctane, known as the most potent inhibitor. The inhibition was competitive with putrescine, similar to cyclohexylamine, and the Ki was 40 nM.
- 公益社団法人日本薬学会の論文
- 1988-08-25
著者
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白幡 晶
城西大学
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白幡 晶
Department of Analytical Chemistry, Faculty of Pharmaceutical Sciences, Josai University
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鮫島 啓二郎
Department of Analytical Chemistry, Faculty of Pharmaceutical Sciences, Josai University
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Samejima K
Faculty Of Pharmaceutical Sciences Josai University
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鮫島 啓二郎
Faculty Of Pharmaceutical Sciences Josai University
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諸星 徹
Department of Analytical Chemistry, Faculty of Pharmaceutical Sciences, Josai University
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諸星 徹
Department Of Analytical Chemistry Faculty Of Pharmaceutical Sciences Josai University
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