On the Benzylation of Nucleosides. II. A Novel Synthesis of 2'-O-Benzyluridine

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概要

• 論文の詳細を見る

• 2'-O-Benzyl-4-methylthiouridine (III) and 2'-O-benzylcytidine (VI) were obtained by respective treatment of 4-methylthiouridine (II) and cytidine (V) with benzyl bromide in the presence of sodium hydride. By this reaction, highly specific benzylation of 2'-hydroxyl group of the ribonucleosides was achieved. The both compounds (III) and (VI) could easily be converted to 2'-O-benzyluridine (IV) which is an important intermediate in the synthesis of oligonucleotide.

• 社団法人日本薬学会の論文
• 1968-06-25

著者

• 鶴尾 隆

  Faculty of Pharmaceutical Sciences, Okayama University

• 鶴尾 隆

  Institute Of Molecular And Cellular Biosciences University Of Tokyo

• 浮田 忠之進

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 井村 伸正

  東京大学薬学部

• 菊川 清見

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 佐藤 史子

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 井村 伸正

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 佐藤 史子

  National Institute Of Radiological Sciences

• 浮田 忠之進

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• 浮田 忠之進

  Faculty Of Pharmaceutical Sciences The University Of Tokyo

関連論文

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