Studies on Azulenes. V. S-Guaiazulene-3-sulfonic Acid.

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概要

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• S-Guaiazulene-sulfonic acid (II), prepared from S-guaiazulene (I) by treatment with sulfur trioxide-dioxane complex was converted into the sodium salt. Treatment of the sodium salt (IV) with phosphoryl chloride gave a monochloro-S-guaiazulene (VI). The same chloro derivative was obtained from 3-acetyl-S-guaiazulene (V) with sodium hypochlorite. However, these chlorination conditions did not give any chloro derivative when applied to S-guaiazulene (I). The chloro derivative thus obtained was identified with a product obtainable from S-guaiazulene (I) by its treatment with N-chlorosuccinimide. Since the structure of 3-acetyl-S-guaiazulene (V) had been confirmed in the preceding paper of this series and as the two chlorination reactions which gave the chloro derivative from the two substituted S-guaiazulenes, (II) and (V), did not give the former directly from S-guaiazulene, it is concluded that the chloro derivative produced from (II) and (V) is 3-chloro-S-guaiazulene and the sulfonated S-guaiazulene (II) is S-guaiazulene-3-sulfonic acid.

• 公益社団法人日本薬学会の論文
• 1957-10-20

著者

• 土師 美恵子

  Government Forest Experiment Station University Of Tokyo

• 渡辺 宏

  The Institute For Infectious Diseases

• 浮田 忠之進

  Pharmaceutical Institute Medical Faculty, and Institute for Infectious Diseases, University of Tokyo

• 宮崎 信

  Government Forest Experiment Station

• 浮田 忠之進

  Faculty Of Pharmaceutical Sciences The University Of Tokyo

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