On the Benzylation of Nucleosides. I. Reaction of Uridine with Benzyl Bromide in the Presence of Sodium Hydride
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概要
- 論文の詳細を見る
Uridine was benzylated with benzyl bromide in the presence of sodium hydride in dimethyl sulfoxide or dimethylformamide to give two products. The one was a dibenzyl uridine (I), yield 33%, and the other N_3-benzyluridine (II), yield 30.5%. The product (I) was converted to the product (II) by catalytic hydrogenation and was identified with N_3,2'-O-dibenzyluridine which was synthesized by detritylation of N_3,2'-O-dibenzyl-3', 5'-di-O-trityluridine (IV) derived by the similar benzylation of the known 3', 5'-di-O-trityluridine (III).
- 社団法人日本薬学会の論文
- 1968-06-25
著者
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鶴尾 隆
Faculty of Pharmaceutical Sciences, Okayama University
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鶴尾 隆
Institute Of Molecular And Cellular Biosciences University Of Tokyo
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浮田 忠之進
Faculty of Pharmaceutical Sciences, University of Tokyo
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井村 伸正
東京大学薬学部
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井村 伸正
Faculty of Pharmaceutical Sciences, University of Tokyo
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浮田 忠之進
Faculty Of Pharmaceutical Sciences University Of Tokyo
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浮田 忠之進
Faculty Of Pharmaceutical Sciences The University Of Tokyo
関連論文
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- On the Benzylation of Nucleosides. II. A Novel Synthesis of 2'-O-Benzyluridine
- On the Benzylation of Nucleosides. I. Reaction of Uridine with Benzyl Bromide in the Presence of Sodium Hydride
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