メチルコバラミン(ビタミンB_<12>アナローグ)による無機水銀の化学的メチル化反応

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概要

• 論文の詳細を見る

• Chemical methylation of inorganic mercurial compounds with methylcobalamin, a vitamin B_<12> analog, was examined. Quantitative determination of methylated mercury by gas chromatography and analysis of the products by thin-layer chromatography revealed that thh methylation proceeded at a markedly high rate by simply mixing methylcobalamin with inorganic mercury, and the reaction gave dimethylmercury as the initial and methylmercury as the final products. Comparative experiments using several other metal halides under the same condition indicated that mercuric chloride is a unique acceptor of the methyl moiety from methylcobalamin among these metal halides tested.

• 社団法人日本薬学会の論文
• 1971-10-30

著者

• 浮田 忠之進

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 井村 伸正

  東京大学薬学部

• 助川 英治

  東京大学薬学部

• 彭 秀光

  東京大学薬学部

• 長尾 清

  東京大学薬学部

• 金 鍾潤

  東京大学薬学部

• 管 孝男

  東京大学薬学部

• 浮田 忠之進

  東京大学薬学部

• 彭 秀光

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 彭 秀光

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• 浮田 忠之進

  Faculty Of Pharmaceutical Sciences University Of Tokyo

関連論文

• Modifications of Nucleosides and Nucleotides. II. Reaction of Ethylene Oxide with 1-Methylcytosine
• 自然界における水銀化合物の変化
• メチルコバラミン(ビタミンB_アナローグ)による無機水銀の化学的メチル化反応
• 水銀の迅速定量分析法に関する研究
• On the Benzylation of Nucleosides. II. A Novel Synthesis of 2'-O-Benzyluridine
• On the Benzylation of Nucleosides. I. Reaction of Uridine with Benzyl Bromide in the Presence of Sodium Hydride
• Organic Phosphates. XIX. A Novel Phosphorylation of Nucleosides and Related Compounds with Hydrobenzoin Cyclic Phosphate activated by Diphenyl Phosphorochloridate.
• Syntheses of Unnatural Pyrimidine Nucleosides
• アルカリ分解成績体の検出による有機リン酸系殺虫剤の同定について
• Organic Phosphates. XI. Syntheses of Several 2', 3'-Cyclic Ribonucleotides and their Properties as Substrate for Ribonuclease.
• Organic Phosphates. X. Several 2,3-Cyclic Phosphates of D-Ribofuranoside and their Properties as Substrate for Ribonuclease.
• Organic Phosphates. IX. An Effective Separation of Flavin Nucleotides and Adenine Nucleotide from Hydrolysates of Flavin Adenine Dinucleotide
• Syntheses of 2,3-Cyclie Ribonucleotides and their Properties as Substrate of Ribonuclease
• Several 2,3-Cyclic Phosphates of D-Ribofuranoside and their Properties as Substrate of Ribonuclease
• Organic Phosphates. IV. Synthesis of Several Bis (2-hydroxyalkyl) and Methyl 2-Hydroxyalkyl Phosphates.
• Organic Phosphates. III. Studies on Alcoholysis of Several Cyclic Phosphates.
• Organic Phosphates. II. Studies on Hydrolysis of Several Cyclic Phosphates.
• Organic Phosphates. I. Synthesis of 1,2-Diol Cyclic Phosphates.
• 局所麻酔薬の微量分析法(第4報) : 脳脊髄液中ジブカインの螢光分析法
• 酸素ボンブ燃焼法による水銀の微量定量法
• アルドリンの光分解
• 毛髪中水銀化合物の酸抽出法による定性定量法
• 局所麻酔剤の微量分析法(III) : 脳脊髄液中の局所麻酔剤の分析法について
• ガスクロマトグラフィーによる酸化防止剤の分析
• On the Synthesis of Uridylyl-(3'→5')-uridine
• Syntheses of 1-(5'-Amino-5'-deoxy-β-D-xylofuranosyl) uracil and Its N_3-Methyl Derivative
• The Syntheses of Glycosylbarbiturate.
• Synthesis of 1-(β-D-Ribofuranosyl) urea and Related Compounds.
• 局所麻酔剤の微量分析法(I) : ガスクロマトグラフィーによる分離
• アルカリ分解成績体の検出による有機リン酸系殺虫剤の同定について(II)
• Organic Phosphates. XIII. Studies on Alkaline Hydrolysis of Cyclic Phosphotriesters.
• Organic Phosphates. XII. Hydrobenzoin Cyclic Phosphoro-chloriodate as a Phosphorylating Agent.
• Reactions of Methyl Iodide on 2,2'-Anhydro-1-(β-D-arabinofuranosyl)-uracil and 2,3'-Anhydro-1-(β-D-xylofuranosyl) uracil
• Reaction of Hydrogen Halides on 2,3'-Anhydro-1-(β-D-xylofuranosyl) uracil
• 化学反応と連鎖
• Studies on Azulenes. IX. 3-(1-Hydroxyethyl)-S-guaiazulene.
• Synthesis of 2'-Deoxy-2'-thio-3'-deoxy-3'-aminouridine.
• Some Attempts on Substitution of 2'-Position of Uridine with Thiol Group.
• Synthesis of 2'-Deoxy-2'-thio-3'-deoxy-3'-aminouridine
• Reaction of Sodium Hypochlorite with Nucleic Acids and Their Constituents
• β-ベンゾイルアクリル酸エチルとリボヌクレオチド類の反応について
• Modifications of Nucleosides and Nucleotides. I. Reaction of Ethylene Oxide with Uridine and Uridylic Acid.
• A Reinvestigation of the Condensation Reaction of Acetobromoglucose with Chloromercuri-4-ethoxy-2 (1H) -pyrimidinone to 1-(Tetra-O-acetyl-β-D-glucopyranosyl)-4-ethoxy-2 (1H)-pyrimidinone.
• Organic Phosphates. XVIII. Syntheses of Lyxouridine 2', 3'-Cyclic Phosphate and Related Compounds.
• In vitro Screening of Tricarbonylmethane and Related Compounds for their Anti-tumor Effect by Cylinder Agar Plate (CAP) Method.
• Organic Phosphates. XIV. Reaction of Catechol Cyclic Phosphate with Monoacetoneglucose ; A Novel Synthesis of D-Glucose 6-Phosphate.
• Synthesis of 2-Deoxy-D-ribose 5-Phosphate
• Organic Phosphates. VIII. A Novel Synthesis of Riboflavin 5'-Phosphate.
• Organic Phosphates. VII. Alcoholyses of Catechol Cyclic Phosphate. (2).
• A Novel Synthesis of DL-Glyceraldehyde 3-Phosphate.
• 放射化分析による毛髪中水銀の定量
• ブロムワレリル尿素製剤のガスクロマトグラフィーによる分析
• 局所麻酔剤の微量分析法(II) : 薄層および前処理ろ紙クロマトグラフィーによる定性
• 生体試料中のエーテルの微量分析法
• 健康人毛髪中の水銀量の居住環境による差異について
• 有機水銀中毒時の尿, 血液, 毛髪中の水銀量について
• 大豆油に添加したBHTの紫外線による分解について
• 生体試料中のTrichloroethyl Phosphateの微量分析
• On the Anti-tumor Activity of Nitrogenous Cyclic β-Diketones.
• Organic Phosphates. XX. Syntheses of 1-(3-Cyanoethylphosphoryl-5-trityl-D-ribofuranosyl)-2(1H)-pyrimidinone, -6(1H)-pyrimidinone, and -2(1H)-pyridone and their Properties as Substrate of Bovine Pancreatic Ribonuclease
• 〔2〕裁判化学上の問題について(殺虫剤による危害とその防止, 特に有機リン製剤について)
• 〔VII〕放射化分析による頭髪中水銀の定量(有害性金属について : 第22回日本薬学大会)
• ガスクロマトグラフィーによるパラ・オルト水素および重水素の分析
• 放射性ストロンチウムによる体内汚染の防禦に関する研究

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