局所麻酔剤の微量分析法(III) : 脳脊髄液中の局所麻酔剤の分析法について
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概要
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The conversion of local anesthetics in human cerebro-spinal fluid was investigated in vitro and an improved method for analysis of the local anesthetics in cerebro-spinal fluid was proposed. When hexylcaine, procaine and tetracaine were incubated with cerebro-spinal fluid, ester bonds of the compounds were hydrolysed mainly due to the increase of pH of cerebro-spinal fluid on standing, while amide bonds of dibucaine, lidocaine and carbocaine were unchanged. In the analysis of local anesthetics in cerebro-spinal fluid, it is desirable to estimate the ultra-violet spectrum of the sample and to determine the aromatic carboxylic acid liberated, as well as the determination of the unchanged anesthetics.
- 社団法人日本薬学会の論文
- 1966-06-30
著者
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浮田 忠之進
Faculty of Pharmaceutical Sciences, University of Tokyo
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浮田 忠之進
東京大学薬学部
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武田 寧
東京大学薬学部薬害研究施設
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星野 乙松
東京大学薬学部
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丹沢 珪子
東京大学薬学部薬害研究施設
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武田 寧
国立衛生研究所
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浮田 忠之進
Faculty Of Pharmaceutical Sciences University Of Tokyo
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