生体試料中のTrichloroethyl Phosphateの微量分析

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概要

• 論文の詳細を見る

• Trichloroethyl phoshate is a hypnotic and this is hydrolyzed rapidly by phosphatases in the body. This paper deals with the results of an investigation on hydrolysis of trichloroethyl phosphate in vitro and the recoveries of trochloroethanol and trichloroethyl phosphate from biological materials. Hydrolysis was carried out in 0.1N HCl, 0.1N NaOH, or 0.1M formate buffer (pH 4.0) at 100°, and with calf intestinal alkaline phosphomonoesterase at 37°. The reaction using the phosphomonoesterase gave the best result in the hydrolysis of trichloroethyl phosphate. Trichloroethanol was found most stable under this condition. Recoveries of trichloroethanol and trichloroethyl phosphate added to human blood plasma and to an artificial gastric content were almost quantitative. In these experiments, amount of trichloroethanol was estimated by the method of Lieberman and Hindman.

• 公益社団法人日本薬学会の論文
• 1966-04-25

著者

• 浮田 忠之進

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 浮田 忠之進

  東京大学薬学部

• 星野 乙松

  東京大学薬学部

• 長谷川 嘉成

  東京大学薬学部

• 浮田 忠之進

  Faculty Of Pharmaceutical Sciences University Of Tokyo

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