Binding and Aggregation of Human γ-Globulin by cis-Diamminedichloroplatinum (II) through Disulfide Bond

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概要

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• The incubation of γ-globulin with cis-diamminedichloroplatinum (II) (cis-DDP) resulted in gradual formation of insoluble aggregates. Since the precipitate, composed of polymerized γ-globulin and cis-DDP, were completely solubilized with urea, the reaction mixture containing precipitate was examined in terms of the binding of cis-DDP and the effect on disulfide (S-S) bonds in the γ-globulin. When γ-globulin was incubated with 30 molar excess cis-DDP at pH 7.4 and 37℃, cis-DDP gradually bound to as much as 12mol per mol of γ-globulin in 14d. Concurrently, about four disulfide bonds were cleaved without reaching a certain plateau. An sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) of the aggregated γ-globulin induced by cis-DDP was significantly different from that of the heat-denaturated aggregate form or the reduced form by sulfitolysis. The aquated complexes of cis-DDP also produced an insoluble precipitate and affected the S-S bond to a greater extent than the parent drug.

• 公益社団法人日本薬学会の論文
• 1994-12-15

著者

• 陳 丹〓

  Faculty of Pharmaceutical Sciences, Osaka University

• 太田 直子

  Faculty Of Pharmaceutical Sciences Nagoya City University

• 権田 良子

  Kyoritsu College of Pharmacy

• 鵜飼 真理

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 益田 美穂子

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 権田 良子

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 鵜飼 真理

  Faculty Of Pharmaceutical Sciences Nagoya City University

• 益田 美穂子

  聖隷クリストファー看護大学 看護

• 陳 丹〓

  Faculty Of Pharmaceutical Sciences Osaka University

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