Characterization of a Polysaccharide Having Activity on the Reticuloendothelial System from the Stolon of Glycyrrhiza globra var. glandulifera

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概要

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• An acid polysaccharide, named glycyrrhizan GA, was isolated form the stolon of Glycyrrhiza glabra L. var. glandulifera REG.et HERD. It produced a single band on electrophoresis and a single peak on gel chromatography, and its molecular mass was estimated to be 85000. Glycyrrhizan GA is composed of L-arabinose : D-galactose : L-rhamnose : D-galacturonic acid : D-glucuronic acid in the molar ratio of 22 : 10 : 1 : 2 : 1,in addition to small amounts of O-acetyl groups. Part of the hexuronic acid residues exist as methyl esters. Methylation analysis, carbon-13 nuclear magnetic resonance and periodate oxidation studies indicated that its structural features include mainly α-arabino-β-3,6-galactan type structural units. Glycyrrhizan GA showed remarkable reticuloendothelial system-potentiating activity in a carbon clearance test.

• 社団法人日本薬学会の論文
• 1991-08-25

著者

• 清水 訓子

  Kyoritsu College Of Pharmacy

• 友田 正司

  Kyoritsu College of Pharmacy

• 権田 良子

  Kyoritsu College of Pharmacy

• 大原 直子

  Kyoritsu College of Pharmacy

• 佐藤 希子

  Kyoritsu College Of Pharmacy

• 佐藤 麻希子

  Kyoritsu College of Pharmacy

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