Characterization of Two Novel Polysaccharides Having Immunological Activities from the Root of Panax ginseng

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概要

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• Two acidic polysaccharides, called ginsenan-S-IA and ginsenan S-IIA, were isolated from the root of Panax ginseng C. A. MEYER. They were homogeneous on electrophoresis and gel chromatography, and their molecular masses were estimated to be 5.6×10^4 and 1.0×10^5,respectively. Ginsenan S-IA is composed of L-arabinose : D-galactose : D-galacturonic acid in the molar ratio of 8 : 8 : 1,and ginsenan S-IIA is composed of L-arabinose : D-galactose : D-glucose : D-galacturonic acid in the molar ratio of 15 : 10 : 2 : 5,in addition to small amounts of O-acetyl groups. About a half (ginsenan S-IA) and about a quarter (ginsenan S-IIA) of the hexuronic acid residues exist as methyl esters. Reduction of carboxyl groups, methylation analysis, nuclear magnetic resonance and periodate oxidation studies indicated that their structural features include mainly α-1,5-linked L-arabino-β-3,6-branched D-galactan type structural units. Both polysaccharides showed remarkable reticuloendothelial system-potentiating activity in a carbon clearance test and pronounced anti-complementary activity. These substances are the first examples having a relatively high content of both α-3,5-branched L-arabinose and β-1,4-linked D-galactose units among the acidic arabinogalactans with activities on phagocytosis and anti-complement.

• 社団法人日本薬学会の論文
• 1993-11-15

著者

• 高田 勝利

  Kyoritsu College Of Pharmacy

• 清水 訓子

  Kyoritsu College Of Pharmacy

• 友田 正司

  Kyoritsu College of Pharmacy

• 権田 良子

  Kyoritsu College of Pharmacy

• 大原 直子

  Kyoritsu College of Pharmacy

• 平林 啓子

  Kyoritsu College of Pharmacy

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